Evidence map›Paper›PMID 30959907›Full record

ArticleMarine drugs2019

Phomaketide A Inhibits Lymphangiogenesis in Human Lymphatic Endothelial Cells.

Huai-Ching Tai, Tzong-Huei Lee, Chih-Hsin Tang, Lei-Po Chen, Wei-Cheng Chen, Ming-Shian Lee, Pei-Chi Chen, Chih-Yang Lin, Chih-Wen Chi, Yu-Jen Chen and 5 more

Open access · goldAbstract read
In one paragraph

Article in Marine drugs, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
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  3. Modeling lymphangiogenesis: Pairing in vitro and in vivo metrics.Microcirculation (New York, N.Y. : 1994) · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 8 institutions in 1 country.

Huai-Ching TaiSchool of Medicine, Fu-Jen Catholic University, New Taipei City 242, Taiwan. taihuai48@hotmail.com.
Tzong-Huei LeeInstitute of Fisheries Science, National Taiwan University, Taipei 106, Taiwan. thlee1@ntu.edu.tw.
Chih-Hsin TangChinese Medicine Research Center, China Medical University, Taichung 404, Taiwan. chtang@mail.cmu.edu.tw.ORCID 0000-0002-7113-8352
Lei-Po ChenDepartment of Orthopaedics, MacKay Memorial Hospital, Taipei 104, Taiwan. robert82ccc@gmail.com.
Wei-Cheng ChenDepartment of Orthopaedics, MacKay Memorial Hospital, Taipei 104, Taiwan. wchena7648@gmail.com.
Ming-Shian LeeInstitute of Fisheries Science, National Taiwan University, Taipei 106, Taiwan. d301101010@tmu.edu.tw.
Pei-Chi ChenDepartment of Medicine, Mackay Medical College, New Taipei City 252, Taiwan. 1622689043new@gmail.com.
Chih-Yang LinDepartment of Medicine, Mackay Medical College, New Taipei City 252, Taiwan. p123400@hotmail.com.
Chih-Wen ChiDepartment of Medical Research, MacKay Memorial Hospital, New Taipei City 251, Taiwan. d48906003@yahoo.com.tw.
Yu-Jen ChenDepartment of Medical Research, MacKay Memorial Hospital, New Taipei City 251, Taiwan. chenmdphd@gmail.com.
Cheng-Ta LaiDivision of Colon and Rectal Surgery, Department of Surgery, MacKay Memorial Hospital, Taipei 104, Taiwan. laichengta@gmail.com.
Shiou-Sheng ChenDivision of Urology, Taipei City Hospital HepingFuyou Branch, Taipei 100, Taiwan. DAB67@tpech.gov.tw.
Kuang-Wen LiaoPh.D. Degree Program of Biomedical Science and Engineering, National Chiao Tung University, Hsinchu 300, Taiwan. liaonms@pchome.com.tw.
Chien-Hsing LeeDepartment of Pharmacology, Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan. chlee0818@gmail.com.
Shih-Wei WangDepartment of Medicine, Mackay Medical College, New Taipei City 252, Taiwan. shihwei@mmc.edu.tw.ORCID 0000-0001-7522-6352
Mackay Memorial Hospital · TWNational Yang Ming Chiao Tung University · TWKaohsiung Medical University · TWMackay Medical University · TWNational Taiwan University · TWAsia University · TWFu Jen Catholic University · TWNational United University · TW

Funding

Mackay Medical College MMC-1071B27Mackay Memorial Hospital MMH-108-94Ministry of Science and Technology, Taiwan MOST 106-2320-B-715-001-MY3; MOST 107-2320-B-030-005Taipei City Hospital TCH 10701-62-027
6 · The paper itself

Abstract

Lymphangiogenesis is an important biological process associated with cancer metastasis. The development of new drugs that block lymphangiogenesis represents a promising therapeutic strategy. Marine fungus-derived compound phomaketide A, isolated from the fermented broth of

Indexed as

A549 CellsAngiogenesis InhibitorsAnimalsAntinematodal AgentsAquatic OrganismsAscomycotaEndothelial CellsHumansLymphangiogenesisLymphatic MetastasisLymphatic VesselsMaleMiceMice, NudeNeoplasmsNitric Oxide Synthase Type IIIAngiogenesis InhibitorsAntinematodal AgentsFLT4 protein, humanNitric Oxide Synthase Type IIINOS3 protein, humanPolyketidesPRKCD protein, humanProtein Kinase C-deltaVascular Endothelial Growth Factor Receptor-3lymphangiogenesislymphatic endothelial cellsphomaketide Avascular endothelial growth factor receptor-3

Identifiers

PMID30959907
PMCPMC6520718
OpenAlexW2933248985

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.