ArticleMetabolites2019
Drying Enhances Signal Intensities for Global GC⁻MS Metabolomics.
Article in Metabolites, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed.
- A role of pigment epithelium-derived factor in zinc-mediated mechanism of neurodegeneration in glaucoma.Communications biology · 2025Article
- Article
- Evaluation of normalization strategies for GC-based metabolomics.Metabolomics : Official journal of the Metabolomic Society · 2024Article
- Optimising a urinary extraction method for non-targeted GC-MS metabolomics.Scientific reports · 2023Article
- Denoising Autoencoder Normalization for Large-Scale Untargeted Metabolomics by Gas Chromatography-Mass Spectrometry.Metabolites · 2023Article
- Sugars dominate the seagrass rhizosphere.Nature ecology & evolution · 2022Article
- Metabolomic Studies for the Evaluation of Toxicity Induced by Environmental Toxicants on Model Organisms.Metabolites · 2021Review
- A review of strategies for untargeted urinary metabolomic analysis using gas chromatography-mass spectrometry.Metabolomics : Official journal of the Metabolomic Society · 2020Review
- Marine Metabolomics: a Method for Nontargeted Measurement of Metabolites in Seawater by Gas Chromatography-Mass Spectrometry.mSystems · 2019Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
We report here that a straightforward change of the standard derivatization procedure for GC⁻MS metabolomics is leading to a strong increase in metabolite signal intensity. Drying samples between methoxymation and trimethylsilylation significantly increased signals by two- to tenfold in extracts of yeast cells, plant and animal tissue, and human urine. This easy step reduces the cost of sample material and the need for expensive new hardware.
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Registered trials
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