Evidence map›Paper›PMID 30959831›Full record

ArticleNutrients2019

Micronutrients Deficiencies in 374 Severely Malnourished Anorexia Nervosa Inpatients.

Mouna Hanachi, Marika Dicembre, Claire Rives-Lange, Jacques Ropers, Pauline Bemer, Jean-Fabien Zazzo, Joël Poupon, Agnès Dauvergne, Jean-Claude Melchior

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 4 pooled it
9.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 4 syntheses or guidelines pooled it, 79 citations in OpenAlex.

  1. Pooled it
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  14. Excessive vitamin BJournal of eating disorders · 2025
    Article
  15. Zinc levels in severe eating disorders.Journal of eating disorders · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 1 country.

Mouna HanachiNutrition Unit, Raymond Poincaré University Hospital (Assistance Publique⁻Hôpitaux de Paris), 92380 Garches, France. mouna.hanachi@aphp.fr.ORCID 0000-0002-7228-8723
Marika DicembreNutrition Unit, Raymond Poincaré University Hospital (Assistance Publique⁻Hôpitaux de Paris), 92380 Garches, France. marika.dic@libero.it.
Claire Rives-LangeNutrition Unit, Georges Pompidou University Hospital (Assistance Publique⁻Hôpitaux de Paris), 75015 Paris, France. claireriveslange@hotmail.fr.
Jacques RopersClinical Research Unit, Pitié-Salpêtrière University Hospital, (Assistance Publique⁻Hôpitaux de Paris, 75013 Paris, France. jacques.ropers@aphp.fr.
Pauline BemerNutrition Unit, Raymond Poincaré University Hospital (Assistance Publique⁻Hôpitaux de Paris), 92380 Garches, France. pauline.bemer@aphp.fr.
Jean-Fabien ZazzoNutrition Unit, Raymond Poincaré University Hospital (Assistance Publique⁻Hôpitaux de Paris), 92380 Garches, France. jfzazzo@hotmail.fr.
Joël PouponLaboratory of Biological Toxicology, Saint Louis⁻Lariboisiere, University Hospital Paris France, 75010 Paris, France. joel.poupon@aphp.fr.
Agnès DauvergneLaboratory of Biochemistry, Beaujon University Hospital (Assistance Publique⁻Hôpitaux de Paris), 92110 Clichy, France. agnes.dauvergne@aphp.fr.
Jean-Claude MelchiorNutrition Unit, Raymond Poincaré University Hospital (Assistance Publique⁻Hôpitaux de Paris), 92380 Garches, France. jean-claude.melchior@aphp.fr.
Assistance Publique – Hôpitaux de Paris · FRUniversité de Versailles Saint-Quentin-en-Yvelines · FRDélégation Paris 5 · FRHôpital Beaujon · FRHôpital Lariboisière · FRSorbonne Université · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionAnorexia nervosa (AN) is a complex psychiatric disorder, which can lead to specific somatic complications. Undernutrition is a major diagnostic criteria of AN and it can be associated with several micronutrients deficiencies.

objectivesThis study aimed to determinate the prevalence of micronutrients deficiencies and to compare the differences between the two subtypes of AN (restricting type (AN-R) and binge-eating/purging type (AN-BP)).

methodsWe report a large retrospective, monocentric study of patients that were hospitalized in a highly specialized AN inpatient unit between January 2011 and August 2017 for severe malnutrition treatment in the context of anorexia nervosa.

resultsThree hundred and seventy-four patients were included, at inclusion, with a mean Body Mass Index (BMI) of 12.5 ± 1.7 kg/m². Zinc had the highest deficiency prevalence 64.3%, followed by vitamin D (54.2%), copper (37.1%), selenium (20.5%), vitamin B1 (15%), vitamin B12 (4.7%), and vitamin B9 (8.9%). Patients with AN-BP type had longer disease duration history, were older, and had a lower left ventricular ejection fraction (LVEF) (

conclusionSeverely malnourished AN patients have many micronutrient deficiencies. Micronutrients status must be monitored and supplemented to prevent deficiency related complications and to improve nutritional status. Prospective studies are needed to explore the symptoms and consequences of each deficiency, which can aggravate the prognosis during recovery.

Indexed as

AdultAnorexia NervosaCohort StudiesFemaleHumansMaleMalnutritionMicronutrientsRetrospective StudiesYoung AdultMicronutrientsanorexia nervosacoppermalnutritionmicronutrientsseleniumvitamin B1vitamin B12vitamin B9vitamin Dzinc

Identifiers

PMID30959831
PMCPMC6520973
OpenAlexW2926996569

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.