Evidence map›Paper›PMID 30959804›Full record

ReviewInternational journal of molecular sciences2019

Insights into Actin-Myosin Interactions within Muscle from 3D Electron Microscopy.

Kenneth A Taylor, Hamidreza Rahmani, Robert J Edwards, Michael K Reedy

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. The cryo-EM 3D image reconstruction of isolated Lethocerus indicus Z-discs.Journal of muscle research and cell motility · 2023
    Review
  2. Article
  3. Article
  4. Regulatory Light Chains in Cardiac Development and Disease.International journal of molecular sciences · 2021
    Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Kenneth A TaylorFlorida State University, Institute of Molecular Biophysics, Tallahassee, FL 32306-4380, USA. taylor@biol.fsu.edu.
Hamidreza RahmaniFlorida State University, Institute of Molecular Biophysics, Tallahassee, FL 32306-4380, USA. hr13b@my.fsu.edu.ORCID 0000-0003-0222-6989
Robert J EdwardsDuke University Medical Center, Department of Cell Biology, Durham, NC 27607, USA. rj.perz-edwards@duke.edu.
Michael K ReedyDuke University Medical Center, Department of Cell Biology, Durham, NC 27607, USA. michael.reedy@duke.edu.

Funding

EM STUDIES ON MUSCLER01GM030598 · NIGMS · FLORIDA STATE UNIVERSITY · PI TAYLOR, KENNETH ALLEN · 1985 to 2020
$4.9M
MYOFIBRILLAR STRUCTURE OF STRIATED MUSCLER01AR014317 · NIAMS · DUKE UNIVERSITY · PI EDWARDS, ROBERT JON · 1986 to 2016
$2.1M
NIGMS NIH HHS R01 GM030598NIH HHS R01 AR014317NIH HHS R01 GM30598
6 · The paper itself

Abstract

Much has been learned about the interaction between myosin and actin through biochemistry, in vitro motility assays and cryo-electron microscopy (cryoEM) of F-actin, decorated with myosin heads. Comparatively less is known about actin-myosin interactions within the filament lattice of muscle, where myosin heads function as independent force generators and thus most measurements report an average signal from multiple biochemical and mechanical states. All of the 3D imaging by electron microscopy (EM) that has revealed the interplay of the regular array of actin subunits and myosin heads within the filament lattice has been accomplished using the flight muscle of the large water bug

Indexed as

Cryoelectron MicroscopyImaging, Three-DimensionalActinsAnimalsFrozen SectionsMusclesMyosinsActinsMyosinsimage reconstructionmuscle physiologystriated muscle

Identifiers

PMID30959804
PMCPMC6479483

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.