Evidence map›Paper›PMID 30959765›Full record

ArticleInternational journal of molecular sciences2019

1,2,4-Oxadiazole/2-Imidazoline Hybrids: Multi-target-directed Compounds for the Treatment of Infectious Diseases and Cancer.

Anton Shetnev, Sergey Baykov, Stanislav Kalinin, Alexandra Belova, Vladimir Sharoyko, Anton Rozhkov, Lev Zelenkov, Marina Tarasenko, Evgeny Sadykov, Mikhail Korsakov and 1 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Synthesis of 1,2,4-Oxadiazin-5(6Molecules (Basel, Switzerland) · 2024
    Article
  3. Article
  4. Article
  5. Room Temperature Synthesis of Bioactive 1,2,4-Oxadiazoles.International journal of molecular sciences · 2023
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Editorial for Special Issue "Bioactive Oxadiazoles".International journal of molecular sciences · 2021
    Article
  12. Novel 1,2,4-Oxadiazole Derivatives in Drug Discovery.Pharmaceuticals (Basel, Switzerland) · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Anton ShetnevPharmaceutical Technology Transfer Center, Ushinsky Yaroslavl State Pedagogical University, 108 Respublikanskaya St., Yaroslavl 150000, Russia. a.shetnev@yspu.org.ORCID 0000-0002-4389-461X
Sergey BaykovInstitute of Chemistry, Saint Petersburg State University, 26 Universitetskii Pr, Peterhof, Saint Petersburg 198504, Russia. s.baykov@spbu.ru.
Stanislav KalininInstitute of Chemistry, Saint Petersburg State University, 26 Universitetskii Pr, Peterhof, Saint Petersburg 198504, Russia. stanislaw.k@mail.ru.
Alexandra BelovaPharmaceutical Technology Transfer Center, Ushinsky Yaroslavl State Pedagogical University, 108 Respublikanskaya St., Yaroslavl 150000, Russia. a.belova@yspu.org.
Vladimir SharoykoInstitute of Chemistry, Saint Petersburg State University, 26 Universitetskii Pr, Peterhof, Saint Petersburg 198504, Russia. v.sharoyko@spbu.ru.
Anton RozhkovInstitute of Chemistry, Saint Petersburg State University, 26 Universitetskii Pr, Peterhof, Saint Petersburg 198504, Russia. a.rozhkov@spbu.ru.ORCID 0000-0002-8658-7281
Lev ZelenkovInstitute of Chemistry, Saint Petersburg State University, 26 Universitetskii Pr, Peterhof, Saint Petersburg 198504, Russia. chemleo@protonmail.ch.ORCID 0000-0001-6387-7553
Marina TarasenkoYaroslavl State Technical University, 88 Moscowsky Pr, Yaroslavl 150023, Russia. mkarunnaya@mail.ru.ORCID 0000-0001-5720-2664
Evgeny SadykovA.E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch Russian Academy of Science, 1 Favorsky Str, Irkutsk 664033, Russian. esadyk.chem@gmail.com.
Mikhail KorsakovPharmaceutical Technology Transfer Center, Ushinsky Yaroslavl State Pedagogical University, 108 Respublikanskaya St., Yaroslavl 150000, Russia. m.korsakov@yspu.org.
Mikhail KrasavinInstitute of Chemistry, Saint Petersburg State University, 26 Universitetskii Pr, Peterhof, Saint Petersburg 198504, Russia. m.krasavin@spbu.ru.

Funding

Russian Foundation for Basic Research 18-33-01108
6 · The paper itself

Abstract

Replacement of amide moiety with the 1,2,4-oxadiazole core in the scaffold of recently reported efflux pump inhibitors afforded a novel series of oxadiazole/2-imidazoline hybrids. The latter compounds exhibited promising antibacterial activity on both Gram-positive (

Indexed as

Anti-Bacterial AgentsBacteriaCell DeathCell Line, TumorCell SurvivalCommunicable DiseasesHumansImidazolesMicrobial Sensitivity TestsMonoamine Oxidase InhibitorsNeoplasmsOxadiazoles2-imidazolineAnti-Bacterial AgentsImidazolesMonoamine Oxidase InhibitorsOxadiazoles1,2,4-oxadiazole2-imidazolinesantibacterialcytotoxicityMAO inhibition

Identifiers

PMID30959765
PMCPMC6480344

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.