Evidence map›Paper›PMID 30959750›Full record

ArticleJournal of clinical medicine2019

Safety and Efficacy of Erythrocyte Encapsulated Thymidine Phosphorylase in Mitochondrial Neurogastrointestinal Encephalomyopathy.

Michelle Levene, Murray D Bain, Nicholas F Moran, Niranjanan Nirmalananthan, Joanna Poulton, Mauro Scarpelli, Massimiliano Filosto, Hanna Mandel, Andrew D MacKinnon, Lynette Fairbanks and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 53 citations in OpenAlex.

  1. Article
  2. Article
  3. Advances in Management of Mitochondrial Myopathies.International journal of molecular sciences · 2025
    Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. A clinical approach to diagnosis and management of mitochondrial myopathies.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2024
    Review
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Therapy Prospects for Mitochondrial DNA Maintenance Disorders.International journal of molecular sciences · 2021
    Review
  17. Nucleic Acid Delivery with Red-Blood-Cell-Based Carriers.International journal of molecular sciences · 2021
    Review
  18. Article
  19. Review
  20. Pregnancy in MNGIE: a clinical and metabolic honeymoon.Annals of clinical and translational neurology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 9 institutions in 3 countries.

Michelle LeveneMolecular and Clinical Sciences, St. George's, University of London, London, SW17 ORE, UK. mlevene@sgul.ac.uk.
Murray D BainMolecular and Clinical Sciences, St. George's, University of London, London, SW17 ORE, UK. mdbain@sgul.ac.uk.
Nicholas F MoranDepartment of Neuroscience, East Kent Hospitals Foundation Trust, Canterbury, CT1 3NG, UK. nickmoran@nhs.net.
Niranjanan NirmalananthanDepartments of Neurology and Neuroradiology, Atkinson Morley Regional Neurosciences Centre, St George's Hospital, London, SW17 0QT, UK. n.nirmalananthan@nhs.net.ORCID 0000-0003-3052-422X
Joanna PoultonNuffield Department of Obstetrics and Gynaecology, University of Oxford, Oxford, OX3 9DU, UK. joanna.poulton@obs-gyn.ox.ac.uk.
Mauro ScarpelliNeurology Unit, Azienda Ospedaliera Universitaria Integrata Verona, Piazzale Aristide Stefani, 1, 37126 Verona, Italy. mauro.scarpelli@aovr.veneto.it.
Massimiliano FilostoCenter for Neuromuscular Diseases, Unit of Neurology, ASST Spedali Civili and University of Brescia, 25100 Brescia, Italy. massimiliano.filosto@unibs.it.ORCID 0000-0002-2852-7512
Hanna MandelGalilee Medical Center, Nahariya 22100, Israel. hanam2@gmc.gov.il.
Andrew D MacKinnonDepartments of Neurology and Neuroradiology, Atkinson Morley Regional Neurosciences Centre, St George's Hospital, London, SW17 0QT, UK. andrew.mackinnon@stgeorges.nhs.uk.
Lynette FairbanksThe Purine Research Laboratory, St Thomas' Hospital, London SE1 7EH, UK. Lynette.Fairbanks@viapath.co.uk.ORCID 0000-0001-7236-9796
Dario PacittiCollege of Medicine and Health, St Luke's Campus, University of Exeter, EX1 2LU, UK. d.pacitti@exeter.ac.uk.ORCID 0000-0002-6230-0266
Bridget E BaxMolecular and Clinical Sciences, St. George's, University of London, London, SW17 ORE, UK. bebax@sgul.ac.uk.ORCID 0000-0001-6306-080X
St George's, University of London · GBAtkins (United Kingdom) · GBAzienda Ospedaliera Universitaria Integrata Verona · ITEast Kent Hospitals University NHS Foundation Trust · GBSt Thomas' Hospital · GBUniversity of Brescia · ITUniversity of Exeter · GBUniversity of Oxford · GBWestern Galilee Hospital · IL

Funding

Medical Research Council G0800674Medical Research Council G0902179Medical Research Council GO90217Medical Research Council KO25406Medical Research Council MR/J010448/1Medical Research Council MR/K025406/1United Mitochondrial Disease Foundation 08-004
6 · The paper itself

Abstract

Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is an ultra-rare autosomal recessive disorder of nucleoside metabolism that is caused by mutations in the nuclear thymidine phosphorylase gene (

Indexed as

enzyme replacementmitochondrial diseaseMitochondrial neurogastrointestinal encephalomyopathyMitochondrial neurogastrointestinal encephalomyopathy (MNGIE)nuclear thymidine phosphorylase gene (TYMP)orphan diseaserare diseasethymidine phosphorylase

Identifiers

PMID30959750
PMCPMC6517976
OpenAlexW2929555794

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.