Evidence map›Paper›PMID 30959739›Full record

ArticleMolecules (Basel, Switzerland)2019

In Vitro and In Silico Acetylcholinesterase Inhibitory Activity of Thalictricavine and Canadine and Their Predicted Penetration across the Blood-Brain Barrier.

Jakub Chlebek, Jan Korábečný, Rafael Doležal, Šárka Štěpánková, Daniel I Pérez, Anna Hošťálková, Lubomír Opletal, Lucie Cahlíková, Kateřina Macáková, Tomáš Kučera and 2 more

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 39 citations in OpenAlex.

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  7. Cholinesterase Inhibitory andCNS & neurological disorders drug targets · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Jakub ChlebekADINACO Research Group, Department of Pharmaceutical Botany, Faculty of Pharmacy, Charles University, Akademika Heyrovského 1203, 500 05 Hradec Králové, Czech Republic. jakub.chlebek@faf.cuni.cz.ORCID 0000-0002-0697-5242
Jan KorábečnýBiomedical Research Center, University Hospital Hradec Králové, Sokolská 581, 500 05 Hradec Králové, Czech Republic. korabecny.jan1@gmail.com.ORCID 0000-0001-6977-7596
Rafael DoležalBiomedical Research Center, University Hospital Hradec Králové, Sokolská 581, 500 05 Hradec Králové, Czech Republic. rafael.dolezal@gmail.com.
Šárka ŠtěpánkováDepartment of Biological and Biochemical Sciences, Faculty of Chemical Technology, University of Pardubice, Studentská 95, 532 10 Pardubice, Czech Republic. Sarka.Stepankova@upce.cz.ORCID 0000-0002-1969-5258
Daniel I PérezCentro de Investigaciones Biológicas, Avenida Ramiro de Maetzu 9, 280 40 Madrid, Spain. dperez@cib.csic.es.
Anna HošťálkováADINACO Research Group, Department of Pharmaceutical Botany, Faculty of Pharmacy, Charles University, Akademika Heyrovského 1203, 500 05 Hradec Králové, Czech Republic. HOSTA4AA@faf.cuni.cz.ORCID 0000-0003-3205-3767
Lubomír OpletalADINACO Research Group, Department of Pharmaceutical Botany, Faculty of Pharmacy, Charles University, Akademika Heyrovského 1203, 500 05 Hradec Králové, Czech Republic. opletal@faf.cuni.cz.
Lucie CahlíkováADINACO Research Group, Department of Pharmaceutical Botany, Faculty of Pharmacy, Charles University, Akademika Heyrovského 1203, 500 05 Hradec Králové, Czech Republic. cahlikova@faf.cuni.cz.ORCID 0000-0002-1555-8870
Kateřina MacákováADINACO Research Group, Department of Pharmaceutical Botany, Faculty of Pharmacy, Charles University, Akademika Heyrovského 1203, 500 05 Hradec Králové, Czech Republic. macakovak@faf.cuni.cz.
Tomáš KučeraDepartment of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defense, Třebešská 1575, 500 01 Hradec Králové, Czech Republic. tomas.kucera2@unob.cz.ORCID 0000-0001-6650-1738
Martina HrabinováBiomedical Research Center, University Hospital Hradec Králové, Sokolská 581, 500 05 Hradec Králové, Czech Republic. martina.hrabinova@unob.cz.ORCID 0000-0002-9428-4109
Daniel JunBiomedical Research Center, University Hospital Hradec Králové, Sokolská 581, 500 05 Hradec Králové, Czech Republic. daniel.jun@unob.cz.ORCID 0000-0002-0882-6304
Charles University · CZUniversity Hospital Hradec Králové · CZCentro de Investigaciones Biológicas Margarita Salas · ESUniversity of Defence · CZUniversity of Pardubice · CZ

Funding

Charles University SVV 260 412 and Nr. 17/2012/UNCE
6 · The paper itself

Abstract

In recent studies, several alkaloids acting as cholinesterase inhibitors were isolated from

Indexed as

AcetylcholinesteraseAlkaloidsAlzheimer DiseaseBerberineBiological TransportBlood-Brain BarrierButyrylcholinesteraseCholinesterase InhibitorsComputer SimulationCorydalisDisaccharidesHumansModels, MolecularNitro CompoundsProtein BindingAcetylcholinesteraseAlkaloidsBerberineButyrylcholinesterasecanadineCholinesterase InhibitorsDisaccharidesNitro Compoundsthalictricosideblood–brain barrier permeability(+)-canadinecholinesteraseskinetic studymolecular docking(+)-thalictricavine

Identifiers

PMID30959739
PMCPMC6480038
OpenAlexW2928890382

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.