ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2019
Hypophagia induced by hindbrain serotonin is mediated through central GLP-1 signaling and involves 5-HT2C and 5-HT3 receptor activation.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 29 citations in OpenAlex.
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- The psychedelic-peptide paradox: a hormetic hypothesis.Comprehensive psychoneuroendocrinology · 2025Review
- Ventral hippocampus neurons encode meal-related memory.Nature communications · 2025Article
- Serotonin signaling to regulate energy metabolism: a gut microbiota perspective.Life metabolism · 2025Review
- Glucagon-Like Peptide-1 Links Ingestion, Homeostasis, and the Heart.Comprehensive Physiology · 2025Review
- A Light-Responsive Neural Circuit Suppresses Feeding.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- GLP-1 receptor agonists: A novel pharmacotherapy for binge eating (Binge eating disorder and bulimia nervosa)? A systematic review.Journal of clinical & translational endocrinology · 2024Review
- Variability in feed intake the first days following weaning impacts gastrointestinal tract development, feeding patterns, and growth performance in nursery pigs.Journal of animal science · 2024Article
- Screening study of anti-emetics to improve GDF15-induced malaise and anorexia: Implications for emesis control.Physiology & behavior · 2023Article
- Adenosine Monophosphate-activated Protein Kinase (AMPK) in serotonin neurons mediates select behaviors during protracted withdrawal from morphine in mice.Behavioural brain research · 2022Article
- The Regulatory Role of the Central and Peripheral Serotonin Network on Feeding Signals in Metabolic Diseases.International journal of molecular sciences · 2022Review
- Serotonin receptors and their association with the immune system in the gastrointestinal tract of weaning piglets.Porcine health management · 2022Article
- Serotonin system genes contribute to the susceptibility to obesity in Black adolescents.Obesity science & practice · 2021Article
- Selective serotonin receptor stimulation of the ventral tegmentum differentially affects appetitive motivation for sugar on a progressive ratio schedule of reinforcement.Behavioural brain research · 2021Article
- Activation of PPG neurons following acute stressors differentially involves hindbrain serotonin in male rats.Neuropharmacology · 2021Article
- GDF15 Induces Anorexia through Nausea and Emesis.Cell metabolism · 2020Article
- Involvement of Peripheral Opioid Receptors in the Realization of Food Motivation Into Eating Behavior.Frontiers in behavioral neuroscience · 2020Article
- Synaptic Inputs to the Mouse Dorsal Vagal Complex and Its Resident Preproglucagon Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
The overlap in neurobiological circuitry mediating the physiological and behavioral response to satiation and noxious/stressful stimuli are not well understood. The interaction between serotonin (5-HT) and glucagon-like peptide-1 (GLP-1) could play a role as upstream effectors involved in mediating associations between anorectic and noxious/stressful stimuli. We hypothesize that 5-HT acts as an endogenous modulator of the central GLP-1 system to mediate satiation and malaise in rats. Here, we investigate whether interactions between central 5-HT and GLP-1 signaling are behaviorally and physiologically relevant for the control of food intake and pica (i.e., behavioral measure of malaise). Results show that the anorexia and body weight changes induced by administration of exogenous hindbrain 5-HT are dependent on central GLP-1 receptor signaling. Furthermore, anatomical evidence shows mRNA expression of 5-HT2C and 5-HT3 receptors on GLP-1-producing preproglucagon (PPG) neurons in the medial nucleus tractus solitarius by fluorescent in situ hybridization, suggesting that PPG neurons are likely to express both of these receptors. Behaviorally, the hypophagia induced by the pharmacological activation of both of these receptors is also dependent on GLP-1 signaling. Finally, 5-HT3, but not 5-HT2C receptors, are required for the anorectic effects of the interoceptive stressor LiCl, suggesting the hypophagia induced by these 5-HT receptors may be driven by different mechanisms. Our findings highlight 5-HT as a novel endogenous modulator of the central GLP-1 system and suggest that the central interaction between 5-HT and GLP-1 is involved in the control of food intake in rats.
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