ReviewEcho research and practice2019
Left atrial spontaneous echo contrast: relationship with clinical and echocardiographic parameters.
Review in Echo research and practice, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- Intracardiac versus transesophageal echocardiography for diagnosis of left atrial appendage thrombosis in atrial fibrillation: A meta-analysis.Clinical cardiology · 2021Pooled it
- Minimally Invasive Standalone Left Atrial Appendage Occlusion for Atrial Fibrillation: Procedural Approaches and Complications.Journal of clinical medicine · 2026Review
- A multivariable prediction model for left atrial appendage spontaneous echo contrast in patients with atrial fibrillation: development and external validation.BMC cardiovascular disorders · 2026Article
- Multiple Coronary-Cameral Fistulae Draining Exclusively Into the Left Atrium Associated With Atrial Thrombosis.Cureus · 2026Article
- Differentiating LAA Thrombus From Spontaneous Echo Contrast for Safe LAA Occlusion.JACC. Case reports · 2026Article
- Early activation of Virchow's triad in feline hypertrophic cardiomyopathy: beyond spontaneous echo contrast and insights into translational thromboembolism.Frontiers in veterinary science · 2026Review
- The Dilemma in the Management of Patients with Heart Failure with Reduced Ejection Fraction, Sinus Rhythm and Left Ventricular Spontaneous Echo Contrast: A Narrative Review.Current cardiology reviews · 2026Review
- Prediction of spontaneous echo contrast following mitral valve transcatheter edge-to-edge repair.International journal of cardiology. Heart & vasculature · 2025Article
- Left atrial appendage thrombus detection in routine workflow for patients with atrial fibrillation under oral anticoagulation: transoesophageal echocardiography vs. cardiac computed tomography.European heart journal. Imaging methods and practice · 2025Article
- Impact of Left Atrial Appendage Morphology and Function on Thrombosis Risk in Acute Ischemic Stroke: Insights from Transesophageal Echocardiography.Medical sciences (Basel, Switzerland) · 2025Article
- Echocardiographic assessment of left atrial appendage morphology and function-an expert proposal by the German Working Group of Cardiovascular Ultrasound.Clinical research in cardiology : official journal of the German Cardiac Society · 2025Review
- Association between the triglyceride-glucose index and left atrial appendage thrombogenic milieu in patients with atrial fibrillation.Frontiers in cardiovascular medicine · 2025Article
- Construction of an early warning model for venous thromboembolism risk in patients with severe cerebral hemorrhage based on ultrasound spontaneous imaging.Frontiers in neurology · 2025Article
- Does Spontaneous Echo Contrast in the Left Atrial Appendage Increase Thromboembolism Risk After Left Atrial Appendage Closure? A Retrospective Study on Its Impact on Device-Related Thrombosis and Arterial Thromboembolic Events.Cardiovascular therapeutics · 2025Article
- Plasma metabolomic characteristics of atrial fibrillation patients with spontaneous echo contrast.BMC cardiovascular disorders · 2024Article
- Article
- Automated Spontaneous Echo Contrast Detection Using a Multisequence Attention Convolutional Neural Network.Ultrasound in medicine & biology · 2024Article
- Is spontaneous echo contrast associated with device-related thrombus or embolic events after left atrial appendage occlusion? - Insights from the multicenter German LAARGE registry.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2024Article
- Left atrial Thrombus formation after discontinuation of anticoagulation in patient with severe bioprosthetic mitral stenosis.BMC cardiovascular disorders · 2023Review
- Choosing Appropriate Candidates for Left Atrial Appendage Occlusion.Reviews in cardiovascular medicine · 2023Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Spontaneous echo contrast (SEC) indicates blood stasis in cardiac chambers and major vessels, and is a known precursor of thrombus formation. Transesophageal echocardiography plays a pivotal role in detecting and grading SEC in the left atrial (LA) cavity. Assessing LA SEC can identify patients at increased risk for thromboembolic events. LA SEC also develops in patients who have sinus rhythm, especially in those with heart failure. Detection of LA SEC is not uncommon in subjects who have multiple cardiovascular comorbidities, although mechanisms behind this association are not fully understood. In patients with atrial fibrillation, the role of mitral regurgitation in counteracting LA SEC and subsequent thromboembolism is controversial. Moreover, alterations of blood coagulability and elevated levels of certain biological markers in the blood contribute to occurrence of LA SEC. This review describes the pathogenesis and assessment of SEC, in addition to the relationship between LA SEC and clinical, biological and echocardiographic parameters.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.