Evidence map›Paper›PMID 30959341›Full record

ArticleJournal of neuroimmunology2019

An investigation into the immune response of cultured neural rat cells following Zika virus infection.

Jennifer H Lawrence, Morgan L Sherer, Phaedra Tavlarides-Hontz, Mark S Parcells, Jaclyn M Schwarz

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroimmunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Jennifer H LawrenceUniversity of Delaware, Department of Psychological and Brain Sciences, 108 Wolf Hall, Newark, DE 19716, USA. Electronic address: jenniferhlawrence@gmail.com.
Morgan L ShererUniversity of Delaware, Department of Psychological and Brain Sciences, 108 Wolf Hall, Newark, DE 19716, USA. Electronic address: msherer@psych.udel.edu.
Phaedra Tavlarides-HontzUniversity of Delaware, Department of Animal and Food Sciences, 052 Townsend Hall, Newark, DE 19716, USA. Electronic address: phaedra@udel.edu.
Mark S ParcellsUniversity of Delaware, Department of Animal and Food Sciences, 052 Townsend Hall, Newark, DE 19716, USA. Electronic address: parcells@udel.edu.
Jaclyn M SchwarzUniversity of Delaware, Department of Psychological and Brain Sciences, 108 Wolf Hall, Newark, DE 19716, USA. Electronic address: jschwarz@psych.udel.edu.
University of Delaware · US

Funding

Long-term impact of prenatal ZIKV infection on neurogenesisR21HD096309 · NICHD · UNIVERSITY OF DELAWARE · PI SCHWARZ, JACLYN MARIE · 2019 to 2020
$431k
NICHD NIH HHS R21 HD096309
6 · The paper itself

Abstract

The most notable effect of prenatal Zika virus (ZIKV) infection is severe microcephaly. ZIKV has a selective tropism for neural progenitor cells; however, it is not clear what role the immune cells of the brain, microglia, may have in mitigating or exacerbating neuronal cell death following ZIKV infection. We cultured hippocampal and cortical neural cells from neonatal rat pups and infected them with ZIKV at various multiplicities of infection (MOI). We found that the neuroimmune response to ZIKV infection is composed of both pro-inflammatory and type I interferon responses and is largely dependent upon the viral dose.

Indexed as

2',5'-Oligoadenylate SynthetaseAnimalsAnimals, NewbornCells, CulturedCerebral CortexFemaleHippocampusInterferon-betaInterleukin-6MaleMicrogliaMyxovirus Resistance ProteinsNeural Stem CellsRatsViral TropismZika Virus2',5'-Oligoadenylate SynthetaseIl6 protein, ratInterferon-betaInterleukin-6Mx1 protein, ratMyxovirus Resistance ProteinsBrainCytokinesInterferonMicrogliaRatZika virus

Identifiers

PMID30959341
PMCPMC7350658
OpenAlexW2925546326

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.