Evidence map›Paper›PMID 30959264›Full record

ArticleVirology2019

The ability of SAMHD1 to block HIV-1 but not SIV requires expression of MxB.

Cindy Buffone, Juliane Kutzner, Silvana Opp, Alicia Martinez-Lopez, Anastasia Selyutina, Si Ana Coggings, Lydia R Studdard, Lingmei Ding, Baek Kim, Paul Spearman and 2 more

Open access · greenAbstract read
In one paragraph

Article in Virology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
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  4. Article
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  6. Review
  7. A CRISPR-Cas Cure for HIV/AIDS.International journal of molecular sciences · 2023
    Review
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  9. Article
  10. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Cindy BuffoneAlbert Einstein College of Medicine, Microbiology and Immunology, Bronx, NY, 10461, USA.
Juliane KutznerUniversity Hospital Heidelberg, Department of Infectious Diseases, Heidelberg, 69120, Germany.
Silvana OppAlbert Einstein College of Medicine, Microbiology and Immunology, Bronx, NY, 10461, USA.
Alicia Martinez-LopezAlbert Einstein College of Medicine, Microbiology and Immunology, Bronx, NY, 10461, USA.
Anastasia SelyutinaAlbert Einstein College of Medicine, Microbiology and Immunology, Bronx, NY, 10461, USA.
Si Ana CoggingsEmory University, Pediatrics, Atlanta, 30322, Georgia.
Lydia R StuddardEmory University, Pediatrics, Atlanta, 30322, Georgia.
Lingmei DingCincinnati Children's Hospital, Infectious Diseases, Cincinnati, OH, 45229, USA.
Baek KimEmory University, Pediatrics, Atlanta, 30322, Georgia.
Paul SpearmanCincinnati Children's Hospital, Infectious Diseases, Cincinnati, OH, 45229, USA.
Torsten SchallerUniversity Hospital Heidelberg, Department of Infectious Diseases, Heidelberg, 69120, Germany.
Felipe Diaz-GrifferoAlbert Einstein College of Medicine, Microbiology and Immunology, Bronx, NY, 10461, USA. Electronic address: felipe.diaz-griffero@einstein.yu.edu.
Albert Einstein College of Medicine · US

Funding

Role of Cellular Factors in Retroviral Uncoating and Synthesis of Viral DNAR01AI087390 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI DIAZ-GRIFFERO, FELIPE · 2010 to 2024
$6.8M
Training in HIV/AIDS Pathogenesis; Basic and Translational ResearchT32AI007501 · NIAID · YESHIVA UNIVERSITY · PI PRASAD, VINAYAKA R. · 1995 to 2024
$6.6M
Replication fidelity and lentiviral pathogenesisR01AI049781 · NIAID · UNIVERSITY OF ROCHESTER · PI KIM, BAEK · 2002 to 2016
$4.9M
Regulation of SAMHD1 antiviral activityR01AI150455 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI DIAZ-GRIFFERO, FELIPE · 2019 to 2024
$3.3M
SAMHD1 controls dNTP pool and HIV sensitivity to NRTIsR01GM104198 · NIGMS · UNIVERSITY OF ROCHESTER · PI KIM, BAEK · 2012 to 2018
$2.3M
Regulation of SAMHD1 antiviral activityR01GM123540 · NIGMS · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI DIAZ-GRIFFERO, FELIPE · 2016 to 2018
$1.4M
Role of TNPO3 in HIV-1 ReplicationR21AI102824 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI DIAZ-GRIFFERO, FELIPE · 2013 to 2014
$444k
Regulation of SAMHD1 antiviral activityR56AI108432 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI DIAZ-GRIFFERO, FELIPE · 2014 to 2014
$431k
SAMHD1 controls dNTP pool and HIV sensitivity to NRTIsR01AI150451 · NIAID · EMORY UNIVERSITY · PI KIM, BAEK · 2019 to 2019
$311k
NIAID NIH HHS R01 AI049781NIAID NIH HHS R01 AI087390NIAID NIH HHS R01 AI150451NIAID NIH HHS R01 AI150455NIAID NIH HHS R21 AI102824NIAID NIH HHS R56 AI108432NIAID NIH HHS T32 AI007501NIGMS NIH HHS R01 GM104198NIGMS NIH HHS R01 GM123540
6 · The paper itself

Abstract

SAMHD1 is a human restriction factor known to prevent infection of macrophages, resting CD4

Indexed as

Amino Acid MotifsHIV-1HIV InfectionsHumansMacrophagesMyxovirus Resistance ProteinsPhosphorylationProtein BindingSAM Domain and HD Domain-Containing Protein 1Simian Immunodeficiency VirusSpecies SpecificityMX2 protein, humanMyxovirus Resistance ProteinsSAM Domain and HD Domain-Containing Protein 1HIV-1MxBRestriction factorsSAMHD1SIVmac

Identifiers

PMID30959264
PMCPMC6487861
OpenAlexW2931699169

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.