Evidence map›Paper›PMID 30959151›Full record

ArticleThe Journal of steroid biochemistry and molecular biology2019

Circulating 11-oxygenated androgens across species.

Juilee Rege, Scott Garber, Alan J Conley, Ruth M Elsey, Adina F Turcu, Richard J Auchus, William E Rainey

Open access · greenAbstract read
In one paragraph

Article in The Journal of steroid biochemistry and molecular biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 61 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Dehydroepiandrosterone (DHEA) as a tool for conservation.Environmental monitoring and assessment · 2026
    Review
  5. Review
  6. Article
  7. Stress, Well-Being, and Reproduction in Wildlife.Advances in experimental medicine and biology · 2026
    Review
  8. Article
  9. Article
  10. DHEA and Cortisol in Rainbow Trout (Animals : an open access journal from MDPI · 2025
    Article
  11. Review
  12. Article
  13. Human Gonads Do Not Contribute to the Circulating Pool of 11-Oxygenated Androgens.The Journal of clinical endocrinology and metabolism · 2025
    Article
  14. Review
  15. Article
  16. Review
  17. Article
  18. 11-Oxyandrogens from the viewpoint of pediatric endocrinology.Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology · 2022
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Juilee RegeDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, United States.
Scott GarberDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, United States.
Alan J ConleyDepartment of Population Health and Reproduction, School of Veterinary Medicine, University of California-Davis, Davis, CA, United States.
Ruth M ElseyLouisiana Department of Wildlife and Fisheries, Rockefeller Wildlife Refuge, Grand Chenier, LA, United States.
Adina F TurcuDivision of Metabolism, Endocrinology, and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, United States.
Richard J AuchusDivision of Metabolism, Endocrinology, and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, United States; Department of Pharmacology, University of Michigan, Ann Arbor, MI, United States.
William E RaineyDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, United States; Division of Metabolism, Endocrinology, and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, United States. Electronic address: WER@umich.edu.
University of Michigan–Ann Arbor · USLouisiana Department of Wildlife and Fisheries · USUniversity of California, Davis · US

Funding

Michigan Institute for Clinical and Health Research (MICHR)UL1TR002240 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LUMENG, JULIE C, MASHOUR, GEORGE ALEXANDER · 2017 to 2022
$54.9M
Michigan Institute for Clinical and Health Research (MCHR)UL1TR000433 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MASHOUR, GEORGE ALEXANDER · 2012 to 2016
$49.9M
MECHANISMS LEADING TO ADRENAL ZONATIONR01DK043140 · NIDDK · UNIVERSITY OF TEXAS SW MED CTR/DALLAS · PI William E Rainey · 1999 to 2026
$7.2M
Activation of androgen biosynthesis and drug metabolism by cytochrome b5R01GM086596 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI RICHARD J. AUCHUS · 2009 to 2026
$4.8M
Molecular Mechanisms of AdrenarcheR01DK069950 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI RAINEY, WILLIAM E · 2005 to 2019
$4.4M
The contemporary endocrinology of congenital adrenal hyperplasiaK08DK109116 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI TURCU, ADINA F · 2016 to 2020
$832k
NCATS NIH HHS UL1 TR000433NCATS NIH HHS UL1 TR002240NIDDK NIH HHS K08 DK109116NIDDK NIH HHS R01 DK043140NIDDK NIH HHS R01 DK069950NIGMS NIH HHS R01 GM086596
6 · The paper itself

Abstract

The androgen precursors, dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS) are produced in high amounts by the adrenal cortex primarily in humans and a few other primates. The human adrenal also secretes 11-oxygenated androgens (11-oxyandrogens), including 11β-hydroxyandrostenedione (11OHA4), 11-ketoandrostenedione (11KA4), 11β-hydroxytestosterone (11OHT) and 11-ketotestosterone (11KT), of which 11OHT and 11KT are bioactive androgens. The 11-oxyandrogens, particularly 11KT, have been recognized as biologically important testicular androgens in teleost fishes for decades, but their physiological contribution in humans has only recently been established. Beyond fish and humans, however, the presence of 11-oxyandrogens in other species has not been investigated. This study provides a comprehensive analysis of a set of C

Indexed as

AndrogensAnimalsDehydroepiandrosteroneDehydroepiandrosterone SulfateFemaleMaleSpecies SpecificityTestosterone11-ketotestosteroneAndrogensDehydroepiandrosteroneDehydroepiandrosterone SulfateTestosterone11-OxyandrogensAdrenalPrimatesSteroids

Identifiers

PMID30959151
PMCPMC6733521
OpenAlexW2929358998

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.