Trial reportPloS one2019
Caregiver-mediated exercises with e-health support for early supported discharge after stroke (CARE4STROKE): A randomized controlled trial.
Trial report in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 7 syntheses or guidelines pooled it.
- Nonlinear dose-response effects of exercise interventions on post-stroke depression: a systematic review and meta-analysis.Frontiers in public health · 2026Pooled it
- Dyad interventions for health-related quality of life, activity, and participation after stroke: a systematic review.Disability and rehabilitation · 2025Pooled it
- The effects of exercise interventions on depressive symptoms in stroke patients: a systematic review and meta-analysis.Frontiers in physiology · 2025Pooled it
- Early supported discharge for older adults admitted to hospital after orthopaedic surgery: a systematic review and meta-analysis.BMC geriatrics · 2024Pooled it
- Remote interventions for informal caregivers of patients with stroke: a systematic review and meta-analysis.BMJ open · 2023Pooled it
- Telerehabilitation for Family Caregivers of Stroke Survivors: A Systematic Review and Meta-Analysis.Journal of nursing management · 2023Pooled it
- Telerehabilitation services for stroke.The Cochrane database of systematic reviews · 2020Pooled it
- Allied rehabilitation using caregiver-mediated exercises combined with telerehabilitation for stroke (ARMed4Stroke): A randomised controlled trial.Clinical rehabilitation · 2024Trial
- Trial
- Self-directed and caregiver-assisted technology-based interventions in inpatient stroke rehabilitation: A scoping review.Clinical rehabilitation · 2026Article
- Telerehabilitation for Motor Recovery in Adults with Neurological Disorders: A Systematic Review and Meta-Analysis Across Motor Domains, Delivery Models, and Follow-Up Effects.Brain sciences · 2026Review
- Transitional care interventions and outcome measures in stroke rehabilitation: a scoping review.Disability and rehabilitation · 2026Review
- Effects of Exercise-Based Telerehabilitation Programs on Functional Recovery and Related Outcomes After Stroke: A Systematic Review.Healthcare (Basel, Switzerland) · 2026Review
- Dance intervention targeting motor, cognitive, and emotional components in stroke patients and their caregivers: a feasibility study.Frontiers in psychology · 2026Article
- Associations of electronic health literacy with related factors in individuals diagnosed with colorectal cancer: a cross-sectional analysis.Frontiers in public health · 2026Article
- What Is the Optimal Length of Stay for Effective Inpatient Neurorehabilitation? A Retrospective Cohort Study.Health science reports · 2025Article
- eHealth Technologies in Transitional Care Interventions for Stroke Survivors and Caregivers: A Scoping Review.Florence Nightingale journal of nursing · 2025Article
- Quality of life measures for people following stroke: a structured content review.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025Review
- Effects of Exercise on Post-Stroke Depression: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Life (Basel, Switzerland) · 2025Review
- Transitional Care Interventions in Improving Patient and Caregiver Outcomes After Discharge: A Scoping Review.Healthcare (Basel, Switzerland) · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeWe designed an 8-week caregiver-mediated exercise program with e-health support after stroke (CARE4STROKE) in addition to usual care with the aim to improve functional outcome and to facilitate early supported discharge by increasing the intensity of task specific training.
methodsAn observer-blinded randomized controlled trial in which 66 stroke patient-caregiver couples were included during inpatient rehabilitation. Patients allocated to the CARE4STROKE program trained an additional amount of 150 minutes a week with a caregiver and were compared to a control group that received usual care alone. Primary outcomes: self-reported mobility domain of the Stroke Impact Scale 3.0 (SIS) and length of stay (LOS). Secondary outcomes: motor impairment, strength, walking ability, balance, mobility and (Extended) Activities of Daily Living of patients, caregiver strain of caregivers, and mood, self-efficacy, fatigue and quality of life of both patients and caregivers. Outcomes were assessed at baseline, 8 and 12 weeks after randomization.
resultsNo significant between-group differences were found regarding SIS-mobility after 8 (β 6.21, SD 5.16; P = 0.229) and 12 weeks (β 0.14, SD 2.87; P = 0.961), and LOS (P = 0.818). Significant effects in favor of the intervention group were found for patient's anxiety (β 2.01, SD 0.88; P = 0.023) and caregiver's depression (β 2.33, SD 0.77; P = 0.003) post intervention. Decreased anxiety in patients remained significant at the 12-week follow-up (β 1.01, SD 0.40; P = 0.009).
conclusionsThis proof-of concept trial did not find significant effects on both primary outcomes mobility and LOS as well as the secondary functional outcomes. Treatment contrast in terms of total exercise time may have been insufficient to achieve these effects. However, caregiver-mediated exercises showed a favorable impact on secondary outcome measures of mood for both patient and caregiver. CLINICAL
trial registrationNTR4300, URL- http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=4300.
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