ArticlePloS one2019
Heat shock in C. elegans induces downstream of gene transcription and accumulation of double-stranded RNA.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Dogcatcher2: Improved statistical detection of transcriptional readthrough and repetitive element analysis across sequencing platforms.bioRxiv : the preprint server for biology · 2026Article
- TDP-43 proteinopathies and neurodegeneration: insights from Caenorhabditis elegans models.The FEBS journal · 2026Review
- Regulatory Mechanisms and Functional Roles of Readthrough Transcripts in Tumorigenesis.International journal of molecular sciences · 2025Review
- RNA Sequencing Experimental Analysis Workflow Using Caenorhabditis elegans.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Simple models to understand complex disease: 10 years of progress fromFrontiers in neuroscience · 2023Review
- The Thermal Stress Coping Network of the NematodeInternational journal of molecular sciences · 2022Review
- It's a DoG-eat-DoG world-altered transcriptional mechanisms drive downstream-of-gene (DoG) transcript production.Molecular cell · 2022Review
- Rapid structure-function insights via hairpin-centric analysis of big RNA structure probing datasets.NAR genomics and bioinformatics · 2021Article
- ARTDeco: automatic readthrough transcription detection.BMC bioinformatics · 2020Article
- Article
- Changes to the TDP-43 and FUS Interactomes Induced by DNA Damage.Journal of proteome research · 2020Article
- Remodeling of the Caenorhabditis elegans non-coding RNA transcriptome by heat shock.Nucleic acids research · 2019Article
- What about the males? theJournal of neurogeneticsArticle
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
We observed that heat shock of Caenorhabditis elegans leads to the formation of nuclear double-stranded RNA (dsRNA) foci, detectable with a dsRNA-specific monoclonal antibody. These foci significantly overlap with nuclear HSF-1 granules. To investigate the molecular mechanism(s) underlying dsRNA foci formation, we used RNA-seq to globally characterize total RNA and immunoprecipitated dsRNA from control and heat shocked worms. We find a subset of both sense and antisense transcripts enriched in the dsRNA pool by heat shock overlap with dsRNA transcripts enriched by deletion of tdp-1, which encodes the C. elegans ortholog of TDP-43. Interestingly, transcripts involved in translation are over-represented in the dsRNAs induced by either heat shock or deletion of tdp-1. Also enriched in the dsRNA transcripts are sequences downstream of annotated genes (DoGs), which we globally quantified with a new algorithm. To validate these observations, we used fluorescence in situ hybridization (FISH) to confirm both antisense and downstream of gene transcription for eif-3.B, one of the affected loci we identified.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.