Evidence map›Paper›PMID 30958695›Full record

Trial reportFASEB journal : official publication of the Federation of American Societies for Experimental Biology2019

Tam T T Tran, Simone Corsini, Lee Kellingray, Claire Hegarty, Gwénaëlle Le Gall, Arjan Narbad, Michael Müller, Noemi Tejera, Paul W O'Toole, Anne-Marie Minihane and 1 more

Registry-linked trialOpen access · hybridAbstract readClinical Trial
In one paragraph

Trial report in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05905822 (DIetary plAnt Extracts, Colonic MicrObes, and Apoe geNetics Interactions stuDy), which is not on this map. Cited by 144 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
144citing papers in PubMed, 2 pooled it
8.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05905822 completednot on this mapstarted 2023, after this paper: background citation

DIetary plAnt Extracts, Colonic MicrObes, and Apoe geNetics Interactions stuDy

TypeobservationalSponsorUniversity of East AngliaRan2023 to 2025Enrolled49ConditionsAlzheimer Disease
3 · Its place in the literature

Who cites it

144 citing papers in PubMed, 2 syntheses or guidelines pooled it, 225 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Review
  6. Rapamycin increases cerebral blood flow and modulates metabolic, inflammatory, and microbiome profiles in healthy middle-aged APOE4 carriers: A pilot single-arm trial.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026
    Article
  7. Alterations of gut microbiota in Down syndrome and their association with Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Review
  19. Review
  20. Review

84 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Tam T T TranAlimentary Pharmabiotic Centre (APC) Microbiome Ireland, University College Cork, Cork, Ireland.
Simone CorsiniNorwich Medical School, University of East Anglia, Norwich, United Kingdom; and.
Lee KellingrayQuadram Institute Bioscience, Norwich Research Park, Norwich, United Kingdom.
Claire HegartyAlimentary Pharmabiotic Centre (APC) Microbiome Ireland, University College Cork, Cork, Ireland.
Gwénaëlle Le GallQuadram Institute Bioscience, Norwich Research Park, Norwich, United Kingdom.
Arjan NarbadQuadram Institute Bioscience, Norwich Research Park, Norwich, United Kingdom.
Michael MüllerNorwich Medical School, University of East Anglia, Norwich, United Kingdom; and.
Noemi TejeraNorwich Medical School, University of East Anglia, Norwich, United Kingdom; and.
Paul W O'TooleAlimentary Pharmabiotic Centre (APC) Microbiome Ireland, University College Cork, Cork, Ireland.
Anne-Marie MinihaneNorwich Medical School, University of East Anglia, Norwich, United Kingdom; and.
David VauzourNorwich Medical School, University of East Anglia, Norwich, United Kingdom; and.
University of East Anglia · GBNorwich Research Park · GBAPC Microbiome Institute · IEUniversity College Cork · IE

Funding

Biotechnology and Biological Sciences Research Council BBS/E/F/00044453Biotechnology and Biological Sciences Research Council BBS/E/F/000PR10353Biotechnology and Biological Sciences Research Council BBS/E/F/000PR10356
6 · The paper itself

Abstract

Apolipoprotein E (

Indexed as

Alzheimer DiseaseApolipoproteins ECognitive DysfunctionGastrointestinal MicrobiomeGenotypeAgedAnimalsButyric AcidFemaleHumansMaleMiceMice, TransgenicMiddle AgedRetrospective StudiesApoE protein, humanApolipoproteins EButyric Acidapolipoprotein Ebutyrategut microbiotametabolomicsSCFAs

Identifiers

PMID30958695
PMCPMC6593891
OpenAlexW2937882491

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.