SynthesisJAMA neurology2019
Endovascular Thrombectomy as a Means to Improve Survival in Acute Ischemic Stroke: A Meta-analysis.
Synthesis in JAMA neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 5 syntheses or guidelines pooled it, 57 citations in OpenAlex.
- Intra-arterial thrombolysis agents following endovascular thrombectomy for acute ischemic stroke: a network meta-analysis.Frontiers in pharmacology · 2026Pooled it
- Efficacy and safety of intra-arterial thrombolysis after endovascular reperfusion for acute ischemic stroke: a systematic review and meta-analysis of randomized trials.International journal of surgery (London, England) · 2025Pooled it
- Different types of percutaneous endovascular interventions for acute ischemic stroke.The Cochrane database of systematic reviews · 2023Pooled it
- Endovascular thrombectomy in acute ischemic stroke patients with prestroke disability (mRS ≥2): A systematic review and meta-analysis.Frontiers in neurology · 2022Pooled it
- Endovascular thrombectomy and intra-arterial interventions for acute ischaemic stroke.The Cochrane database of systematic reviews · 2021Pooled it
- Association of tirofiban treatment with outcomes following endovascular therapy in cardioembolic stroke: insights from the RESCUE BT randomized trial.European journal of medical research · 2023Trial
- The incidence and impact of early post-stroke seizures for successful endovascular stroke treatment: an individual patient data level analysis of trials.International journal of surgery (London, England) · 2026Article
- Multimodal CT radiomics-clinical ensemble machine learning model effectively predicts futile recanalization after endovascular treatment of acute ischemic stroke.Frontiers in neuroscience · 2026Article
- Heart rate and clinical outcome after endovascular treatment in patients with anterior versus posterior circulation large vessel occlusion.Therapeutic advances in neurological disorders · 2026Article
- Predictive value of preoperative and postoperative controlling nutritional status scores and their changes in older patients with large vessel occlusion stroke after endovascular thrombectomy.Frontiers in nutrition · 2026Article
- Serum Metabolome Profiling Reveals Biomarkers to Predict Malignant Brain Edema Following Endovascular Stroke Therapy.Translational stroke research · 2025Observational
- Temporal Trends in Public Stroke Awareness in Korea, 2009 to 2023.Journal of the American Heart Association · 2025Article
- Lower CALLY index levels indicate higher poor functional outcome risk in acute ischemic stroke patients treated with endovascular thrombectomy.Frontiers in aging neuroscience · 2025Article
- Clearance rate of contrast extravasation after endovascular therapy is associated with functional outcome and mediated by cerebral edema.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2025Article
- Elevated MPV: A Key Indicator of Acute Anterior Circulation Stroke Prognosis in Mechanical Thrombectomy.Therapeutics and clinical risk management · 2025Article
- High-frequency repetitive transcranial magnetic stimulation protects against cerebral ischemia/reperfusion injury in rats: Involving the mitigation of ferroptosis and inflammation.Brain and behavior · 2023Article
- Association between collaterals, cerebral circulation time and outcome after thrombectomy of stroke.Annals of clinical and translational neurology · 2023Article
- Contrast enhancement by location and volume is associated with long-term outcome after thrombectomy in acute ischemic stroke.Scientific reports · 2022Article
- Global disease burden of stroke attributable to high fasting plasma glucose in 204 countries and territories from 1990 to 2019: An analysis of the Global Burden of Disease Study.Journal of diabetes · 2022Article
- Association of the 24-Hour National Institutes of Health Stroke Scale After Mechanical Thrombectomy With Early and Long-Term Survival.Stroke (Hoboken, N.J.) · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Importance: Although endovascular thrombectomy (EVT) in acute ischemic stroke is recommended by guidelines to improve functional recovery, thus far there are insufficient data on its association with mortality. Objective: To identify guideline-relevant trials of EVT vs medical therapy reporting 90-day mortality and perform a meta-analysis. Data Sources: All randomized clinical trials cited for recommendations on EVT vs medical therapy in the latest 2018 American Stroke Association/American Heart Association guidelines. Study Selection: Ten American Stroke Association/American Heart Association guideline-relevant randomized clinical trials of EVT vs medical therapy were selected for inclusion. Two EVT trials were excluded owing to infrequent use of EVT. Data Extraction and Synthesis: Data were abstracted by 2 independent investigators and double-checked by 4 others. Singular study data were integrated using the Cochran-Mantel-Haenszel method and a random-effects model to compute summary statistics of risk ratios (RR) with 95% CIs. Main Outcomes and Measures: Risk of 90-day mortality and 90-day intracranial hemorrhage was analyzed; sensitivity analyses were performed in early-window EVT trials (which included patients from the onset of symptoms onward) vs late-window EVT trials (which included patients from 6 hours after onset of symptoms onward). Results: In 10 trials with 2313 patients, EVT significantly reduced the risk for 90-day mortality by 3.7% compared with medical therapy (15.0% vs 18.7%; RR, 0.81; 95% CI, 0.68-0.98; P = .03). Trends were similar in early-window (RR, 0.83; 95% CI, 0.67-1.01; P = .06) and late-window trials only (RR, 0.76; 95% CI, 0.41-1.40; P = .38). There was no difference in the risk for intracranial hemorrhage in EVT vs medical therapy (4.2% vs 4.0%; RR, 1.11; 95% CI, 0.71-1.72; P = .65). Limitations of the studies include trial protocol heterogeneity and bias originating from prematurely terminated trials. Conclusions and Relevance: This meta-analysis of all evidence on EVT cited in the 2018 American Stroke Association/American Heart Association guidelines shows significant benefits for survival during the first 90 days after acute ischemic stroke compared with medical therapy alone.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.