ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2020
Identifying Characteristics of Frailty in Female Mice Using a Phenotype Assessment Tool.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 34 citations in OpenAlex.
- Ghrelin Receptor Deletion or Pharmacological Inhibition Improves Muscle Function in Aging Male Mice.Aging cell · 2026Article
- Could animal models be used to longitudinally track intrinsic capacity during aging?The journal of nutrition, health & aging · 2026Article
- Elevating Circulating L-Kynurenine Promotes Frailty in Aging Mice.Journal of cachexia, sarcopenia and muscle · 2026Article
- CORP: In vivo muscle strength-perspectives on the design and interpretation of preclinical animal studies.American journal of physiology. Regulatory, integrative and comparative physiology · 2025Review
- Frailty Assessment in an Aging Mouse Model.Journal of visualized experiments : JoVE · 2025Article
- Analysis of the current state of frailty indexes and their implementation for aging intervention studies.Aging · 2025Review
- The impact of frailty syndrome on skeletal muscle histology: preventive effects of exercise.FEBS open bio · 2025Article
- Evaluating frailty assessment tools and biological frailty markers in C57BL/6 female mice.GeroScience · 2025Article
- Longitudinal Decline of Exercise Capacity in Male and Female Mice.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Editorial: Clinical uses and alternative approaches of frailty determination.Frontiers in physiology · 2025Article
- Overlapping and Distinct Physical and Biological Phenotypes in Pure Frailty and Obese Frailty.Bioscience reports · 2024Article
- Longitudinal Decline of Exercise Capacity in Male and Female Mice.bioRxiv : the preprint server for biology · 2024Article
- Mouse sarcopenia model reveals sex- and age-specific differences in phenotypic and molecular characteristics.The Journal of clinical investigation · 2024Article
- Unveiling frailty: comprehensive and sex-specific characterization in prematurely aging PolgA mice.Frontiers in aging · 2024Article
- Adaptability to eccentric exercise training is diminished with age in female mice.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- Comprehensive longitudinal non-invasive quantification of healthspan and frailty in a large cohort (n = 546) of geriatric C57BL/6 J mice.GeroScience · 2023Article
- Protectin DX as a therapeutic strategy against frailty in mice.GeroScience · 2023Article
- Neuromuscular mechanisms of weakness in a mouse model of chronic alcoholic myopathy.Alcoholism, clinical and experimental research · 2022Article
- Physiological Systems in Promoting Frailty.Comprehensive Physiology · 2022Review
- Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Preclinical studies are important in identifying the underlying mechanisms contributing to frailty. Frailty studies have mainly focused on male rodents with little directed at female rodents. Therefore, the purposes of this study were to identify the onset and prevalence of frailty across the life span in female mice, and to determine if frailty predicts mortality. Female C57BL/6 (n = 27) mice starting at 17 months of age were assessed across the life span using a frailty phenotype, which included body weight, walking speed, strength, endurance, and physical activity. The onset of frailty occurred at approximately 17 months (1/27 mice), with the prevalence of frailty increasing thereafter. At 17 months, 11.1% of the mice were pre-frail and by 26 months peaked at 36.9%. The percentage of frail mice progressively increased up to 66.7% at 32 months. Non-frail mice lived to 29 months whereas frail/pre-frail mice lived only to 26 months (p = .04). In closing, using a mouse frailty phenotype, we are able to identify that the prevalence of frailty in female mice increases across the life span and accurately predicts mortality. Together, this frailty phenotype has the potential to yield information about the underlying mechanisms contributing to frailty.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.