ArticleJournal of Alzheimer's disease : JAD2019
Associations between Depression, Depressive Symptoms, and Incidence of Dementia in Latin America: A 10/66 Dementia Research Group Study.
Article in Journal of Alzheimer's disease : JAD, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Neurocognitive disorders, depression, and associated factors in younger and older adults from an urban-marginalized area of Peru.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Associations between eating alone, its transition and depressive symptoms among Chinese middle-aged and older adults: evidence from two national cohorts.BMC psychiatry · 2024Article
- Prevalence of depressive disorder in the adult population of Latin America: a systematic review and meta-analysis.Lancet regional health. Americas · 2023Article
- Depressive symptoms mediate the relationship between diabetes and cognitive performance in a community-based sample of older adults.Journal of diabetes and its complications · 2022Article
- Trajectories of depression symptoms over time differ by APOE4 genotype in older adults with type 2 diabetes.International journal of geriatric psychiatry · 2021Article
- Psychological Impact of the Pandemic on Ambulatory Cardiometabolic Patients Without Evidence of SARS-CoV-2 Infection. The CorCOVID Latam Psy Study.Current problems in cardiology · 2021Article
- Increase in Number of Depression Symptoms Over Time is Related to Worse Cognitive Outcomes in Older Adults With Type 2 Diabetes.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2021Article
- Total Plasma Homocysteine and Depressive Symptoms in Older Hispanics.Journal of Alzheimer's disease : JAD · 2021Article
- Late-life depression, subjective cognitive decline, and their additive risk in incidence of dementia: A nationwide longitudinal study.PloS one · 2021Article
- Education in early life markedly reduces the probability of cognitive impairment in later life in Colombia.Scientific reports · 2020Article
- The type 2 diabetes-specific dementia risk score (DSDRS) is associated with frailty, cognitive and functional status amongst Mexican community-dwelling older adults.BMC geriatrics · 2020Article
- Risk Factors for Incident Dementia Among Older Cubans.Frontiers in public health · 2020Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundA growing body of evidence suggests that depression is related to dementia in older adults. Previous research has been done in high-income countries and there is a lack of studies in low- and middle income countries (LMICs).
objectiveTo examine the relationship between depressive symptoms and incidence of dementia in a population-based study of older adults in Latin America.
methodsThe study is a part of the 10/66 Dementia Research Group's population survey and includes 11,472 older adults (baseline mean age 74 years) from Cuba, Dominican Republic, Mexico, Peru, Puerto Rico, and Venezuela. The baseline examinations were done in 2003-2007 and the follow-up examinations 4 years later. Semi-structured psychiatric interviews gave information about ICD-10 depression and sub-syndromal depression (i.e., ≥4 depressive symptoms) at baseline. Information on dementia were collected at the follow-up examination. Competing risk models analyzed the associations between depression and incidence of dementia and the final model were adjusted for age, sex, education, stroke, and diabetes. Separate analyses were conducted for each site and then meta-analyzed by means of fixed effect models.
resultsAt baseline, the prevalence of depression was 26.0% (n = 2,980): 5.4% had ICD-10 depression and 20.6% sub-syndromal depression. During the follow-up period, 9.3% (n = 862) developed dementia and 14.3% (n = 1,329) deceased. In the pooled analyses, both ICD-10 depression (adjusted sub-hazard ratio (sHR) 1.63, 95% confidence interval (CI) 1.26-2.11) and sub-syndromal depression (adjusted sHR 1.28, 95% CI: 1.09-1.51) were associated with increased incidence of dementia. The Higging I2 tests showed a moderate heterogeneity across the study sites.
conclusionOur findings suggest that late-life depression is associated with the incidence of dementia in LMICs in Latin America, which support results from earlier studies conducted in high-income countries.
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