ArticleJournal of Alzheimer's disease : JAD2019
A 2.5-Year Longitudinal Assessment of Naturalistic Driving in Preclinical Alzheimer's Disease.
Article in Journal of Alzheimer's disease : JAD, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 2 syntheses or guidelines pooled it, 63 citations in OpenAlex.
- Early detection of diseases causing dementia using digital navigation and gait measures: A systematic review of evidence.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Pooled it
- Driving among individuals with chronic conditions: A systematic review of applied research using kinematic driving sensors.Journal of the American Geriatrics Society · 2024Pooled it
- Driving the neural exposome: Latent mobility states from naturalistic GPS data in older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Neurophysiological Characteristics Associated with Driving Abilities in Older Adults: A Scoping Review.Journal of clinical medicine · 2026Review
- Human-Centered Multi-Sensor Framework for Identifying Driving Patterns Associated with Cognitive Decline Through Quantitative Analysis.Research square · 2026Article
- White Matter Hyperintensity Burden and Decline in Driving Performance Among Older Adults.JAMA network open · 2026Article
- Association of Daily Driving Behaviors With Mild Cognitive Impairment in Older Adults Followed Over 10 Years.Neurology · 2025Observational
- The neighbourhood built environment affects driving behaviours of older adults: a combined geographic information systems and machine learning method.Cities & health · 2025Article
- Advance and Prospect of Positron Emission Tomography in Alzheimer's disease research.Molecular psychiatry · 2025Review
- Longitudinal associations between plasma biomarkers and changes in naturalistic driving behaviors in older adults.Journal of Alzheimer's disease : JAD · 2025Article
- Early identification of cognitive impairment in older adults from Advanced Activities of Daily Living (AADL): A scoping review.Public health · 2025Article
- Integrating Machine Learning and Environmental and Genetic Risk Factors for the Early Detection of Preclinical Alzheimer's Disease.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025Article
- Identifying major depressive disorder in older adults through naturalistic driving behaviors and machine learning.NPJ digital medicine · 2025Article
- LiveDrive AI: A Pilot Study of a Machine Learning-Powered Diagnostic System for Real-Time, Non-Invasive Detection of Mild Cognitive Impairment.Bioengineering (Basel, Switzerland) · 2025Article
- Characterizing Navigational Changes in Preclinical Alzheimer's Disease: A Route Complexity Metric Derived From Naturalistic Driving Data.IEEE journal of translational engineering in health and medicine · 2025Article
- Smart Driving Technology for Non-Invasive Detection of Age-Related Cognitive Decline.Sensors (Basel, Switzerland) · 2024Article
- Impact of cognitive impairment on driving behaviour and route choices of older drivers: a real-world driving study.Scientific reports · 2024Article
- Digital Neuropsychology beyond Computerized Cognitive Assessment: Applications of Novel Digital Technologies.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2024Review
- Alzheimer's in the modern age: Ethical challenges in the use of digital monitoring to identify cognitive changes.Informatics for health & social care · 2024Article
- Differential Impacts of Road Diets on Driving Behavior among Older Adults with and without Preclinical Alzheimer's Pathology.Transportation research. Part F, Traffic psychology and behaviour · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundEmerging evidence shows that cognitively normal older adults with preclinical Alzheimer's disease (AD) make more errors and are more likely to receive a marginal/fail rating on a standardized road test compared to older adults without preclinical AD, but the extent to which preclinical AD impacts everyday driving behavior is unknown.
objectiveTo examine self-reported and naturalistic longitudinal driving behavior among persons with and without preclinical AD.
methodWe prospectively followed cognitively normal drivers (aged 65 + years) with (n = 10) and without preclinical AD (n = 10) for 2.5 years. Preclinical AD was assessed using amyloid positron emission tomography (PET) with Pittsburgh Compound B. The Driving Habits Questionnaire assessed self-reported driving outcomes. Naturalistic driving was captured using a commercial GPS data logger plugged into the on-board diagnostics II port of each participant's vehicle. Data were sampled every 30 seconds and all instances of speeding, hard braking, and sudden acceleration were recorded.
resultsPreclinical AD participants went to fewer places/unique destinations, traveled fewer days, and took fewer trips than participants without preclinical AD. The preclinical AD group reported a smaller driving space, greater dependence on other drivers, and more difficulty driving due to vision difficulties. Persons with preclinical AD had fewer trips with any aggression and showed a greater decline across the 2.5-year follow-up period in the number of days driving per month and the number of trips between 1-5 miles.
conclusionChanges in driving occur even during the preclinical stage of AD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.