Evidence map›Paper›PMID 30958264›Full record

ArticleeLife2019

Natural variation in

Stefan Zdraljevic, Bennett William Fox, Christine Strand, Oishika Panda, Francisco J Tenjo, Shannon C Brady, Tim A Crombie, John G Doench, Frank C Schroeder, Erik C Andersen

Open access · goldAbstract read
In one paragraph

Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
8.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 80 citations in OpenAlex.

  1. Natural variation suggests candidate genes underlying Caenorhabditis elegans susceptibility to diverse toxicants.Toxicological sciences : an official journal of the Society of Toxicology · 2026
    Article
  2. Persistent effects of early-life arsenic exposure inEnvironmental science. Processes & impacts · 2026
    Article
  3. Conserved Molecular Responses to Arsenite Exposure inbioRxiv : the preprint server for biology · 2026
    Article
  4. High-Throughput Toxicity Screening withEnvironmental science & technology · 2026
    Review
  5. Article
  6. Natural variation suggests candidate genes underlyingbioRxiv : the preprint server for biology · 2025
    Article
  7. Article
  8. Article
  9. Genetic variation in parasite avoidance, yet no evidence for constitutive fitness costs.Evolution; international journal of organic evolution · 2024
    Article
  10. Article
  11. Article
  12. Natural genetic variation in the pheromone production ofProceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  13. Article
  14. Article
  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Stefan ZdraljevicInterdisciplinary Biological Sciences Program, Northwestern University, Evanston, United States.ORCID 0000-0003-2883-4616
Bennett William FoxBoyce Thompson Institute and Department of Chemistry and Chemical Biology, Cornell University, Ithaca, United States.
Christine StrandBroad Institute of MIT and Harvard, Cambridge, United States.
Oishika PandaBoyce Thompson Institute and Department of Chemistry and Chemical Biology, Cornell University, Ithaca, United States.
Francisco J TenjoBoyce Thompson Institute and Department of Chemistry and Chemical Biology, Cornell University, Ithaca, United States.
Shannon C BradyInterdisciplinary Biological Sciences Program, Northwestern University, Evanston, United States.
Tim A CrombieDepartment of Molecular Biosciences, Northwestern University, Evanston, United States.
John G DoenchBroad Institute of MIT and Harvard, Cambridge, United States.ORCID 0000-0002-3707-9889
Frank C SchroederBoyce Thompson Institute and Department of Chemistry and Chemical Biology, Cornell University, Ithaca, United States.
Erik C AndersenInterdisciplinary Biological Sciences Program, Northwestern University, Evanston, United States.ORCID 0000-0003-0229-9651
Northwestern University · USCornell University · USBroad Institute · USBuck Institute for Research on Aging · US

Funding

CELLULAR &MOLECULAR BASIS OF DISEASE TRAINING PROGRAMT32GM008061 · NIGMS · NORTHWESTERN UNIVERSITY · PI CARTHEW, RICHARD W. · 1985 to 2022
$17.1M
Small molecule signaling in C. elegansR35GM131877 · NIGMS · BOYCE THOMPSON INST FOR PLANT RESEARCH · PI Frank Clemens Schroeder · 2019 to 2026
$5.0M
Discovery of conserved molecular mechanisms underlying population-wide variation in toxin responsesR01ES029930 · NIEHS · NORTHWESTERN UNIVERSITY · PI ANDERSEN, ERIK CHRISTIAN, BAUGH, LARRY RYAN · 2019 to 2023
$3.2M
Large scale nutrigenetics and genomics in a tractable metazoan modelR01DK115690 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI ANDERSEN, ERIK CHRISTIAN, SCHROEDER, FRANK CLEMENS · 2017 to 2020
$2.8M
Small Molecule Signaling in Caenorhabditis elegansR01GM088290 · NIGMS · BOYCE THOMPSON INST FOR PLANT RESEARCH · PI SCHROEDER, FRANK CLEMENS · 2010 to 2017
$2.2M
American Cancer Society 127313-RSG-15-135-01-DDNIDDK NIH HHS DK115690NIDDK NIH HHS R01 DK115690NIEHS NIH HHS ES029930NIEHS NIH HHS R01 ES029930NIGMS NIH HHS GM088290NIGMS NIH HHS R01 GM088290NIGMS NIH HHS R35 GM131877NIGMS NIH HHS T32 GM008061NIGMS NIH HHS T32GM008061
6 · The paper itself

Abstract

We find that variation in the Editorial note: This article has been through an editorial process in which the authors decide how to respond to the issues raised during peer review. The Reviewing Editor's assessment is that all the issues have been addressed (see decision letter).

Indexed as

Biological Variation, Population3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide)Amino Acids, Branched-ChainAnimalsArsenicCaenorhabditis elegansGenetic VariationHEK293 CellsHumans3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide)Amino Acids, Branched-ChainArsenicC. elegansenvironmental toxinevolutionary biologygeneticsgenomicshuman cell linesnatural variation

Identifiers

PMID30958264
PMCPMC6453569
OpenAlexW2935729442

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.