Evidence map›Paper›PMID 30958263›Full record

ArticleeLife2019

Nationally-representative serostudy of dengue in Bangladesh allows generalizable disease burden estimates.

Henrik Salje, Kishor Kumar Paul, Repon Paul, Isabel Rodriguez-Barraquer, Ziaur Rahman, Mohammad Shafiul Alam, Mahmadur Rahman, Hasan Mohammad Al-Amin, James Heffelfinger, Emily Gurley

Abstract read
In one paragraph

Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

69 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Epidemiological Characteristics of Dengue Infection in Bangladesh: A Systematic Review.International journal of environmental research and public health · 2026
    Pooled it
  2. Fine-scale heterogeneity inProceedings of the National Academy of Sciences of the United States of America · 2020
    Trial
  3. Trial
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  6. The national burden from O'nyong'nyong and chikungunya viruses in Cameroon.medRxiv : the preprint server for health sciences · 2026
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  11. Potential value streams of an integrated Canadian serosurveillance network.Canadian journal of public health = Revue canadienne de sante publique · 2026
    Article
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  19. Reconciling heterogeneous dengue virus infection risk estimates from different study designs.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  20. Article

9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Henrik SaljeMathematical Modelling of Infectious Diseases Unit, Institut Pasteur, UMR2000, CNRS, Paris, France.ORCID 0000-0003-3626-4254
Kishor Kumar PaulInternational Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.ORCID 0000-0002-6054-3571
Repon PaulInternational Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.
Isabel Rodriguez-BarraquerUniversity of California, San Francisco, San Francisco, United States.ORCID 0000-0001-6784-1021
Ziaur RahmanInternational Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.
Mohammad Shafiul AlamInternational Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.
Mahmadur RahmanInstitute of Epidemiology, Disease Control and Research (IEDCR), Dhaka, Bangladesh.
Hasan Mohammad Al-AminInternational Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.
James HeffelfingerDivision of Global Health Protection, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, United States.
Emily GurleyDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, United States.ORCID 0000-0002-8648-9403

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Serostudies are needed to answer generalizable questions on disease risk. However, recruitment is usually biased by age or location. We present a nationally-representative study for dengue from 70 communities in Bangladesh. We collected data on risk factors, trapped mosquitoes and tested serum for IgG. Out of 5866 individuals, 24% had evidence of historic infection, ranging from 3% in the north to >80% in Dhaka. Being male (aOR:1.8, [95%CI:1.5-2.0]) and recent travel (aOR:1.3, [1.1-1.8]) were linked to seropositivity. We estimate that 40 million [34.3-47.2] people have been infected nationally, with 2.4 million ([1.3-4.5]) annual infections. Had we visited only 20 communities, seropositivity estimates would have ranged from 13% to 37%, highlighting the lack of representativeness generated by small numbers of communities. Our findings have implications for both the design of serosurveys and tackling dengue in Bangladesh.

Indexed as

Cost of IllnessAntibodies, ViralBangladeshDengueFemaleHumansImmunoglobulin GMaleRisk FactorsSeroepidemiologic StudiesSex FactorsTravelAntibodies, ViralImmunoglobulin GBangladeshdengueepidemiologyglobal healthnationally-representativeSeroprevalencevirus

Identifiers

PMID30958263
PMCPMC6513551

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.