ArticleJournal of the Royal Society, Interface2019
It sounds like an action potential: unification of electrical, chemical and mechanical aspects of acoustic pulses in lipids.
Article in Journal of the Royal Society, Interface, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Neurocomputational mechanisms underlying perception and sentience in the neocortex.Frontiers in computational neuroscience · 2024Review
- On mathematical modeling of the propagation of a wave ensemble within an individual axon.Frontiers in cellular neuroscience · 2023Review
- Neuronal Activity in the Sciatic Nerve Is Accompanied by Immediate Cytoskeletal Changes.Frontiers in molecular neuroscience · 2021Article
- High-speed interferometric imaging reveals dynamics of neuronal deformation during the action potential.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In an ongoing debate on the physical nature of the action potential (AP), one group adheres to the electrical model of Hodgkin and Huxley, while the other describes the AP as a nonlinear acoustic pulse propagating within an interface near a transition. However, despite remarkable similarities, acoustics remains a non-intuitive mechanism for APs for the following reason. While acoustic pulses are typically associated with the propagation of density, pressure and temperature variation, APs are most commonly measured electrically. Here, we show that this discrepancy is lifted upon considering the electrical and chemical aspects of the interface, in addition to its mechanical properties. Specifically, we demonstrate how electrical and pH aspects of acoustic pulses emerge from an idealized description of the lipid interface, which is based on classical physical principles and contains no fit parameters. The pulses that emerge from the model show similarities to APs not only in qualitative shape and scales (time, velocity and voltage), but also demonstrate saturation of amplitude and annihilation upon collision.
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