ArticleJournal of the Royal Society, Interface2019
Analysis of productivity and stability of synthetic microbial communities.
Article in Journal of the Royal Society, Interface, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Stability of density-dependent model with indirect feedback and biomass inhibition.Theory in biosciences = Theorie in den Biowissenschaften · 2025Article
- Deciphering and designing microbial communities by genome-scale metabolic modelling.Computational and structural biotechnology journal · 2024Review
- Assembly of functional microbial ecosystems: from molecular circuits to communities.FEMS microbiology reviews · 2024Review
- DyMMM-LEAPS: An ML-based framework for modulating evenness and stability in synthetic microbial communities.Biophysical journal · 2024Article
- Assembly and Function of Seed Endophytes in Response to Environmental Stress.Journal of microbiology and biotechnology · 2023Review
- Enhanced production of heterologous proteins by a synthetic microbial community: Conditions and trade-offs.PLoS computational biology · 2020Article
- Microbial model communities: To understand complexity, harness the power of simplicity.Computational and structural biotechnology journal · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bioreactors that employ a synthetic microbial community hold potential to overcome limitations of those based on a single species, which embrace a higher level of complexity due to the inter-species interactions. In this work, a number of generic system structures involving two cross-feeding species and various types of inhibition have been studied, together with two three-species cases where a third species is introduced to fulfil a specific function. These cases are represented by mathematical models and inspected through bifurcation analysis and numerical simulation to reveal how the system structure and parametrization affect stability and productivity of the bioreactor. The results show that inhibitions generally lead to reduction in both productivity and stability, and that the presence of a negative feedback loop and a positive feedback loop may give rise to oscillation and bi-stability, respectively, depending on the strength of the inhibitions involved. The intended gains by the introduction of a third species may be achieved when its negative side-effect is sufficiently moderate, and at the cost of reduced stability. As observed in several cases, the changes in stability and productivity do not always follow the same trend, implying trade-off between the two objectives in the engineering of such bioreactors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.