Evidence map›Paper›PMID 30958116›Full record

ReviewOpen biology2019

Emerging microRNA biomarkers for colorectal cancer diagnosis and prognosis.

Bing Chen, Zijing Xia, Ya-Nan Deng, Yanfang Yang, Peng Zhang, Hongxia Zhu, Ningzhi Xu, Shufang Liang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Open biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
84citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

84 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
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  6. Article
  7. Review
  8. Article
  9. Role of Exosomal Non-Coding RNAsMicroRNA (Shariqah, United Arab Emirates) · 2026
    Review
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24 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Bing Chen1 State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy , No. 17, 3rd Section of People's South Road, Chengdu 610041 , People's Republic of China.
Zijing Xia1 State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy , No. 17, 3rd Section of People's South Road, Chengdu 610041 , People's Republic of China.
Ya-Nan Deng1 State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy , No. 17, 3rd Section of People's South Road, Chengdu 610041 , People's Republic of China.
Yanfang Yang1 State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy , No. 17, 3rd Section of People's South Road, Chengdu 610041 , People's Republic of China.
Peng Zhang4 Department of Urinary Surgery, West China Hospital, West China Medical School, Sichuan University , Chengdu 610041 , People's Republic of China.
Hongxia Zhu5 Laboratory of Cell and Molecular Biology and State Key Laboratory of Molecular Oncology, Cancer Institute and Cancer Hospital, Chinese Academy of Medical Sciences , Beijing 100034 , People's Republic of China.
Ningzhi Xu1 State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy , No. 17, 3rd Section of People's South Road, Chengdu 610041 , People's Republic of China.
Shufang Liang1 State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy , No. 17, 3rd Section of People's South Road, Chengdu 610041 , People's Republic of China.

Funding

The Role of Brain Stress Systems in the Prefrontal Cortex in Compulsive DrinkingR01AA020608 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI GEORGE, OLIVIER · 2011 to 2015
$1.8M
NIAAA NIH HHS R01 AA020608
6 · The paper itself

Abstract

MicroRNAs (miRNAs) are one abundant class of small, endogenous non-coding RNAs, which regulate various biological processes by inhibiting expression of target genes. miRNAs have important functional roles in carcinogenesis and development of colorectal cancer (CRC), and emerging evidence has indicated the feasibility of miRNAs as robust cancer biomarkers. This review summarizes the progress in miRNA-related research, including study of its oncogene or tumour-suppressor roles and the advantages of miRNA biomarkers for CRC diagnosis, treatment and recurrence prediction. Along with analytical technique improvements in miRNA research, use of the emerging extracellular miRNAs is feasible for CRC diagnosis and prognosis.

Indexed as

Gene Expression Regulation, NeoplasticApoptosisBiomarkers, TumorCell ProliferationColorectal NeoplasmsGene Expression ProfilingHumansMicroRNAsNeoplasm Recurrence, LocalPrognosisBiomarkers, TumorMicroRNAsbiomarkerscolorectal cancerdiagnosis and prognosismicroRNAs

Identifiers

PMID30958116
PMCPMC6367136

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.