Evidence map›Paper›PMID 30957991›Full record

ReviewAdvanced healthcare materials2019

Drug Delivery Strategies for the Treatment of Metabolic Diseases.

Sanjun Shi, Na Kong, Chan Feng, Aram Shajii, Claire Bejgrowicz, Wei Tao, Omid C Farokhzad

Open access · greenAbstract readReview
In one paragraph

Review in Advanced healthcare materials, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 65 citations in OpenAlex.

  1. Review
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  5. Review
  6. Article
  7. Correlation between Complement C1q A Chain (Iranian journal of public health · 2024
    Article
  8. Review
  9. Review
  10. Review
  11. Article
  12. Review
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  14. Article
  15. Article
  16. Review
  17. Regulatory role and mechanism of mMolecular therapy oncolytics · 2021
    Review
  18. Review
  19. Article
  20. RNACell & bioscience · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Sanjun ShiCenter for Nanomedicine and Department of Anesthesiology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
Na KongCenter for Nanomedicine and Department of Anesthesiology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
Chan FengCenter for Nanomedicine and Department of Anesthesiology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
Aram ShajiiCenter for Nanomedicine and Department of Anesthesiology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
Claire BejgrowiczCenter for Nanomedicine and Department of Anesthesiology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
Wei TaoCenter for Nanomedicine and Department of Anesthesiology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.ORCID 0000-0002-4277-3728
Omid C FarokhzadCenter for Nanomedicine and Department of Anesthesiology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.ORCID 0000-0003-2009-270X
Brigham and Women's Hospital · US

Funding

Enhancing Inflammation Resolution in Atherosclerosis via Targeted Nanoparticle-Mediated Delivery of BiologicsR01HL127464 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SHI, JINJUN, TABAS, IRA A · 2016 to 2019
$3.0M
METAvivor Early Career InvestigatorNational Institute of Health HL127464NHLBI NIH HHS R01 HL127464
6 · The paper itself

Abstract

Metabolic diseases occur when normal metabolic processes are disrupted in the human body, which can be congenital or acquired. The incidence of metabolic diseases worldwide has reached epidemic proportions. So far, various methods including systemic drug therapy and surgery are exploited to prevent and treat metabolic diseases. However, current pharmacotherapeutic options for treatment of these metabolic disorders remain limited and ineffective, especially reducing patient compliance to treatment. Therefore, it is desirable to exploit effective drug delivery approaches to effectively treat metabolic diseases and reduce side effects. This brief review summarizes novel delivery strategies including local, targeted, and oral drug delivery strategies, as well as intelligent stimulus-responsive drug delivery strategy, for the treatment of metabolic disorders including diabetes, obesity, and atherosclerosis.

Indexed as

Drug Delivery SystemsAdministration, OralAnimalsHumansMetabolic DiseasesMolecular Targeted TherapyPolymersPolymersbiomaterialsdrug deliverymetabolic diseasesnanomedicine

Identifiers

PMID30957991
PMCPMC6663576
OpenAlexW2937378537

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.