ArticleNucleic acids research2019
The crystal structure of an antiparallel chair-type G-quadruplex formed by Bromo-substituted human telomeric DNA.
Article in Nucleic acids research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- AND-Logic-Gated Aptamer Switch for Precise Targeting and Regulation of RNA G-Quadruplexes.Angewandte Chemie (International ed. in English) · 2026Article
- Topological rules and anomalies in intramolecular G-quadruplex folding: a comprehensive study.Nucleic acids research · 2026Article
- G-Quadruplex Structures Formed by Human Telomere andInternational journal of molecular sciences · 2025Review
- Comprehensive analysis of intramolecular G-quadruplex structures: furthering the understanding of their formalism.Nucleic acids research · 2024Article
- On Water Arrangements in Right- and Left-Handed DNA Structures.Molecules (Basel, Switzerland) · 2024Review
- On the Importance of Halogen and Chalcogen Bonds in the Solid State of Nucleic Acids: A Combined Crystallographic and Theoretical Perspective.International journal of molecular sciences · 2023Article
- SelectiveJournal of medicinal chemistry · 2022Article
- Phen-DCAngewandte Chemie (International ed. in English) · 2022Article
- Epigenomic Features and Potential Functions of KInternational journal of molecular sciences · 2022Article
- Ruthenium Polypyridyl Complex Bound to a Unimolecular Chair-Form G-Quadruplex.Journal of the American Chemical Society · 2022Article
- Oxidative lesions modulate G-quadruplex stability and structure in the human BCL2 promoter.Nucleic acids research · 2021Article
- Water spines and networks in G-quadruplex structures.Nucleic acids research · 2021Article
- The Research of G-Motif Construction and Chirality in Deoxyguanosine Monophosphate Nucleotide Complexes.Frontiers in chemistry · 2021Article
- DNAzymes as Catalysts for l-Tyrosine and Amyloid β Oxidation.ACS omega · 2020Article
- Intra-locked G-quadruplex structures formed by irregular DNA G-rich motifs.Nucleic acids research · 2020Article
- G-quadruplex structures formed by human telomeric DNA and C9orf72 hexanucleotide repeats.Biophysical reviews · 2019Article
- The Biophysical Society of Hong Kong (BPHK): past, present, and future.Biophysical reviews · 2019Article
- Beyond the double helix: DNA structural diversity and the PDB.The Journal of biological chemistryReview
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11 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Human telomeric guanine-rich DNA, which could adopt different G-quadruplex structures, plays important roles in protecting the cell from recombination and degradation. Although many of these structures were determined, the chair-type G-quadruplex structure remains elusive. Here, we present a crystal structure of the G-quadruplex composed of the human telomeric sequence d[GGGTTAGG8GTTAGGGTTAGG20G] with two dG to 8Br-dG substitutions at positions 8 and 20 with syn conformation in the K+ solution. It forms a novel three-layer chair-type G-quadruplex with two linking trinucleotide loops. Particularly, T5 and T17 are coplanar with two water molecules stacking on the G-tetrad layer in a sandwich-like mode through a coordinating K+ ion and an A6•A18 base pair. While a twisted Hoogsteen A12•T10 base pair caps on the top of G-tetrad core. The three linking TTA loops are edgewise and each DNA strand has two antiparallel adjacent strands. Our findings contribute to a deeper understanding and highlight the unique roles of loop and water molecule in the folding of the G-quadruplex.
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