Evidence map›Paper›PMID 30957681›Full record

ArticleJournal of the American Heart Association2019

Prevalence of Unexplained Left Ventricular Hypertrophy by Cardiac Magnetic Resonance Imaging in MESA.

Daniele Massera, Robyn L McClelland, Bharath Ambale-Venkatesh, Antoinette S Gomes, W Gregory Hundley, Nadine Kawel-Boehm, Kihei Yoneyama, David S Owens, Mario J Garcia, Mark V Sherrid and 3 more

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 54 citations in OpenAlex.

  1. Observational
  2. Article
  3. Review
  4. Article
  5. Article
  6. Hypertrophic cardiomyopathy.Nature reviews. Disease primers · 2025
    Review
  7. Review
  8. Observational
  9. Article
  10. The Clinical Impact of SARS-CoV-2 on Hypertrophic Cardiomyopathy.Journal of cardiovascular development and disease · 2024
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. The Feline Cardiomyopathies: 1. General concepts.Journal of feline medicine and surgery · 2021
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 10 institutions in 3 countries.

Daniele Massera1 New York University School of Medicine New York NY.
Robyn L McClelland2 University of Washington Seattle WA.
Bharath Ambale-Venkatesh3 Johns Hopkins School of Medicine Baltimore MD.
Antoinette S Gomes4 University of California Los Angeles CA.
W Gregory Hundley5 Virginia Commonwealth University Health Sciences Richmond VA.
Nadine Kawel-Boehm6 Kantonsspital Graubünden Chur Switzerland.
Kihei Yoneyama7 St. Marianna University School of Medicine Kawasaki Japan.
David S Owens2 University of Washington Seattle WA.
Mario J Garcia8 Montefiore Medical Center Bronx NY.
Mark V Sherrid1 New York University School of Medicine New York NY.
Jorge R Kizer9 San Francisco Veterans Affairs Health Care System and University of California San Francisco San Francisco CA.
Joao A C Lima3 Johns Hopkins School of Medicine Baltimore MD.
David A Bluemke10 University of Wisconsin School of Medicine and Public Health Madison WI.
Johns Hopkins Medicine · USNew York University · USUniversity of Washington · USKantonsspital Graubünden · CHMontefiore Medical Center · USSt. Marianna University School of Medicine · JPUniversity of California, Los Angeles · USUniversity of California, San Francisco · USUniversity of Wisconsin–Madison · USVirginia Commonwealth University · US

Funding

Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1M
Wake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3M
Clinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2M
SUBCLINICAL CARDIOVASCULAR DISEASE COORDINATING CENTERN01HC95159 · NHLBI · UNIVERSITY OF WASHINGTON · PI KRONMAL, RICHARD A · 2007 to 2014
$19.6M
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTERN01HC95160 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WATSON, KAROL · 2007 to 2015
$7.7M
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY-FIELD CENTERN01HC95164 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LIU, KIANG · 2007 to 2015
$7.0M
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTERN01HC95161 · NHLBI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI SHEA, STEVEN · 2007 to 2014
$6.4M
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTERN01HC95165 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI BURKE, GREGORY L · 2007 to 2014
$6.3M
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTERN01HC95163 · NHLBI · UNIVERSITY OF MINNESOTA · PI FOLSOM, AARON R · 2007 to 2014
$6.1M
TITLE: MULTI-ETHNIC STUDY OF ATHEROSCLEROSIS (MESA)N01HC95162 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI POST, WENDY · 2007 to 2015
$6.0M
SUBCLINICAL CARDIOVASCULAR DISEASE STUDYN01HC95166 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI TRACY, RUSSELL P · 2007 to 2014
$4.0M
SUBCLINICAL CARDIOVASCULAR DISEASE STUDYN01HC95168 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI LIMA, JOAO · 2007 to 2015
$2.6M
NCATS NIH HHS UL1 TR000040NCATS NIH HHS UL1 TR001079NCATS NIH HHS UL1 TR001420NHLBI NIH HHS K24 HL135413NHLBI NIH HHS N01HC95159NHLBI NIH HHS N01HC95160NHLBI NIH HHS N01HC95161NHLBI NIH HHS N01HC95162NHLBI NIH HHS N01HC95163NHLBI NIH HHS N01HC95164NHLBI NIH HHS N01HC95165NHLBI NIH HHS N01HC95166NHLBI NIH HHS N01HC95167NHLBI NIH HHS N01HC95168NHLBI NIH HHS N01HC95169
6 · The paper itself

Abstract

Background Hypertrophic cardiomyopathy is defined as unexplained left ventricular ( LV ) hypertrophy (wall thickness ≥15 mm) and is prevalent in 0.2% of adults (1:500) in population-based studies using echocardiography. Cardiac magnetic resonance imaging ( MRI ) allows for more accurate wall thickness measurement across the entire ventricle than echocardiography. The prevalence of unexplained LV hypertrophy by cardiac MRI is unknown. MESA (Multi-Ethnic Study of Atherosclerosis) recruited individuals without overt cardiovascular disease 45 to 84 years of age. Methods and Results We studied 4972 individuals who underwent measurement of regional LV wall thickness by cardiac MRI as part of the MESA baseline exam. American Heart Association criteria were used to define LV segments. We excluded participants with hypertension, LV dilation (≥95% predicted end-diastolic volume) or dysfunction (ejection fraction ≤50%), moderate-to-severe left-sided valve lesions by cardiac MRI , severe aortic valve calcification by cardiac computed tomography (aortic valve Agatston calcium score >1200 in women or >2000 in men), obesity (body mass index >35 kg/m

Indexed as

AgedCardiac-Gated Imaging TechniquesCardiomyopathy, HypertrophicCohort StudiesElectrocardiographyFemaleHumansHypertrophy, Left VentricularMagnetic Resonance ImagingMaleMiddle AgedPrevalenceProspective StudiesUnited Stateshypertrophic cardiomyopathymagnetic resonance imagingpopulation‐based study

Identifiers

PMID30957681
PMCPMC6507185
OpenAlexW2933335834

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.