ArticleOrganic letters2019
Isolation, Structure, and Total Synthesis of the Marine Macrolide Mangrolide D.
Article in Organic letters, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Novel fidaxomicin antibiotics through site-selective catalysis.Communications chemistry · 2021Article
- A convergent approach toward fidaxomicin: Syntheses of the fully glycosylated northern and southern fragments.Tetrahedron · 2020Article
- Combining enyne metathesis with long-established organic transformations: a powerful strategy for the sustainable synthesis of bioactive molecules.Beilstein journal of organic chemistry · 2020Review
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Authors and funding
5 authors.
Funding
Abstract
The isolation, characterization, and total synthesis of the macrocyclic polyene mangrolide D is reported. A 16-step total synthesis relies on robust Suzuki and ring-closing metathesis reactions, and an iron-catalyzed hydroazidation of an exomethylene substituted tetrahydropyran as a key step for the synthesis of the appended 4- epi-vancosamine sugar. Although mangrolide D did not display antibiotic activity, this work should prove enabling toward the synthesis of the antitubercular tiacumicins which display a virtually identical macrocyclic backbone.
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