ArticleThoracic cancer2019
P40 expression in small cell lung cancer: The presence of p40-positive cells does not always indicate squamous differentiation.
Article in Thoracic cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed, 10 citations in OpenAlex.
- Case Report: Neuroendocrine-marker-negative high-grade neuroendocrine carcinoma mimicking squamous cell carcinoma: an underrecognized diagnostic pitfall.Frontiers in immunology · 2026Article
- Evaluation of TTF-1, Napsin A, p40, and p63 in the Subtyping of Non-Small Cell Lung Carcinoma: A Cross-Sectional Study from India.Iranian journal of pathology · 2025Article
- Personalizing non-small cell lung cancer treatment through patient-derived xenograft models: preclinical and clinical factors for consideration.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2024Article
- Oral sarcomatoid squamous cell carcinoma: a retrospective study based on 14 cases.Histology and histopathology · 2020Article
- Expression of neuro-oncological ventral antigen-1 in small-cell lung cancer and its value in pathological diagnosis.Translational cancer research · 2020Article
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8 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundSmall cell lung cancer (SCLC) is normally diagnosed with hematoxylin and eosin stains, although some cases require immunohistochemistry (IHC). P40 is highly sensitive and specific for squamous cell carcinoma and is thus considered the best marker for this cancer. However, the status of p40 expression in SCLC is not well known. The aim of this study was to analyze p40 expression in resected SCLC using IHC.
methodsForty-four surgically resected SCLC cases were enrolled. Clinical data were obtained from the patients' medical records. Pathologists blinded to the patients' clinical data reviewed the SCLC slides. IHC was performed on a representative slide of each case.
resultsAlthough p40 was not diffusely expressed in any of the SCLC cases, p40-positive cells were observed in the tumors in 15 cases (34.1%). Ten of these exhibited p40 in < 1% of tumor cells. In the remaining five cases, 1-5% of tumor cells expressed p40, and in three of these, the cells expressing p40 also expressed TTF-1 and neuroendocrine markers. There was no statistically significant relationship between p40 positivity and any other clinicopathological characteristics.
conclusionsSome resected SCLCs express p40 focally. This result suggests that the presence of positive p40 cells does not exclude a diagnosis of SCLC. Thus, small biopsy or cytology specimens with p40-positive cells must be diagnosed carefully.
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