ArticleMolecular medicine reports2019
miRNA‑15a‑5p facilitates the bone marrow stem cell apoptosis of femoral head necrosis through the Wnt/β‑catenin/PPARγ signaling pathway.
Article in Molecular medicine reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 7 citations in OpenAlex.
- Article
- The DLEU2-miR-15a-16-1 Cluster Is a Determinant of Bone Microarchitecture and Strength in Postmenopausal Women and Mice.International journal of molecular sciences · 2024Article
- Advances in the Pathogenesis of Steroid-Associated Osteonecrosis of the Femoral Head.Biomolecules · 2024Review
- Cellular and Molecular Connections Between Bone Fracture Healing and Exosomes.Physiological research · 2023Review
- Extracellular Vesicles in Bone Homeostasis: Emerging Mediators of Osteoimmune Interactions and Promising Therapeutic Targets.International journal of biological sciences · 2022Review
- A Cancer-Related microRNA Signature Shows Biomarker Utility in Multiple Myeloma.International journal of molecular sciences · 2021Article
- Glucocorticoids induce osteonecrosis of the femoral head through the Hippo signaling pathway.Open life sciences · 2021Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bone marrow stem cells (BMSCs) are a group cells that function as an underlying cell source for bone tissue regeneration. However, the molecular mechanisms of how BMSCs are induced into apoptosis remains unclear. In the present study, it was demonstrated that the molecular mechanisms of BMSCs were exerted via microRNA‑15a‑5p (miR‑15a‑5p) in femoral head necrosis (FHN). Briefly, miRNA‑15a‑5p expression was elevated in a rat model of FHN. Overexpression of miR‑15a‑5p promoted the apoptosis of BMSCs and reduced cell growth through the Wnt/β‑catenin/peroxisome proliferator‑activated receptor γ (PPARγ) signaling pathway. Downregulation of miR‑15a‑5p reduced the apoptosis of BMSCs and promoted cell growth through the Wnt/β‑catenin/PPARγ signaling pathway. The activation of Wnt attenuated the effects of miR‑15a‑5p on the apoptosis of BMSCs via the β‑catenin/PPARγ signaling pathway. In conclusion, the present results indicated that miRNA‑15a‑5p was involved in the regulation of the apoptosis of BMSCs through regulating the Wnt/β‑catenin/PPARγ signaling pathway, which may serve an important role in the regulation of FHN.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.