ArticleThe Journal of infectious diseases2020
Population-Level Antimicrobial Consumption Is Associated With Decreased Antimicrobial Susceptibility in Neisseria gonorrhoeae in 24 European Countries: An Ecological Analysis.
Article in The Journal of infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Mechanisms, management and prevention of anorectal sexually transmitted infections.Nature reviews. Gastroenterology & hepatology · 2026Review
- The Influence of National Antibiotic Consumption on Neisseria Gonorrhoeae Antibiotic Resistance in Norway, 2003-2024.The Journal of infectious diseases · 2026Article
- Enhancing antimicrobial resistance surveillance and research: a systematic scoping review on the possibilities, yield and methods of data linkage studies.Antimicrobial resistance and infection control · 2025Article
- Investigating the cause of increased tetracycline-resistant Neisseria gonorrhoeae in England, 2016-20.The Journal of antimicrobial chemotherapy · 2024Article
- Relationship between Antibiotic Consumption and Resistance: A Systematic Review.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2024Review
- Effect on the Resistome of Dual vs Monotherapy for the Treatment ofOpen forum infectious diseases · 2023Article
- Use of viability PCR for detection of live Chlamydia trachomatis in clinical specimens.Frontiers in reproductive health · 2023Article
- Review
- Tolerance to Ceftriaxone inAntibiotics (Basel, Switzerland) · 2022Article
- Trends and regional variations of gonococcal antimicrobial resistance in the Netherlands, 2013 to 2019.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2022Article
- Screening of Anorectal and Oropharyngeal Samples Fails to Detect Bacteriophages InfectingAntibiotics (Basel, Switzerland) · 2022Article
- Correlation Between Individual Child-Level Antibiotic Consumption and Antibiotic-Resistant Among CommensalInfection and drug resistance · 2022Article
- Establishing Novel Molecular Algorithms to Predict Decreased Susceptibility to Ceftriaxone in Neisseria gonorrhoeae Strains.The Journal of infectious diseases · 2021Review
- WGS of CommensalPathogens (Basel, Switzerland) · 2021Article
- Recent advances in understanding and combattingFaculty reviews · 2021Review
- Gonococcal resistance can be viewed productively as part of a syndemic of antimicrobial resistance: an ecological analysis of 30 European countries.Antimicrobial resistance and infection control · 2020Article
- Article
- The frontiers of addressing antibiotic resistance in Neisseria gonorrhoeae.Translational research : the journal of laboratory and clinical medicine · 2020Review
- CommensalPathogens (Basel, Switzerland) · 2020Article
- Thank Martin Luther that ciprofloxacin could cure your gonorrhoea? Ecological association between Protestantism and antimicrobial consumption in 30 European countries.F1000Research · 2020Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThere are substantial variations between different populations in the susceptibility of Neisseria gonorrhoeae to antimicrobials, and the reasons for this are largely unexplored. We aimed to assess whether the population-level consumption of antimicrobials is a contributory factor.
methodsUsing antimicrobial susceptibility data from 24 countries in the European Gonococcal Antimicrobial Surveillance Programme and antimicrobial consumption data from the IQVIA MIDAS database, we built mixed-effects linear/logistic regression models with country-level cephalosporin, fluoroquinolone, and macrolide consumption (standard doses/1000 population/year) as the explanatory variables (from 2009 to 2015) and 1-year-lagged ceftriaxone, cefixime, azithromycin, and ciprofloxacin geometric mean minimum inhibitory concentrations (MICs) as the outcome variables (from 2010 to 2016).
resultsPositive correlations were found between the consumption of cephalosporins and the geometric mean MICs of ceftriaxone and cefixime (P < .05 for both comparisons). Fluoroquinolone consumption was positively associated with the prevalence of resistance to ciprofloxacin (P < .05).
conclusionsDifferences in the population-level consumption of particular antimicrobials may contribute to variations in the level of antimicrobial resistance in N. gonorrhoeae in different settings. Further interventions to reduce misuse and overuse of antimicrobials in high-consumption populations and core groups are required.
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