ArticleMedicine and pharmacy reports2019
Scrub typhus infection, not a benign disease: an experience from a tertiary care center in Northern India.
Article in Medicine and pharmacy reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- Unveiling the burden of scrub typhus in acute febrile illness cases across India: A systematic review & meta-analysis.The Indian journal of medical research · 2024Pooled it
- Systematic review of the scrub typhus treatment landscape: Assessing the feasibility of an individual participant-level data (IPD) platform.PLoS neglected tropical diseases · 2021Pooled it
- Intravenous Doxycycline, Azithromycin, or Both for Severe Scrub Typhus.The New England journal of medicine · 2023Trial
- Mapping Scrub Typhus Across Multiple Hosts in India.EcoHealth · 2026Review
- Review
- Bioinformatics analysis of Rickettsia typhi autoimmune associations and screening of Streptomyces-derived inhibitors.BioData mining · 2025Article
- Determination of a cut-off value for the serological diagnosis of scrub typhus by detecting anti-The Indian journal of medical research · 2023Article
- Clinical, laboratory, and molecular epidemiology of Orientia tsutsugamushi infection from Southwestern India.PloS one · 2023Article
- Article
- Rickettsiosis with Pleural Effusion: A Systematic Review with a Focus on Rickettsiosis in Italy.Tropical medicine and infectious disease · 2022Review
- Validation of a Clinical Risk-scoring Algorithm for Scrub Typhus Severity in South India.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2021Article
- Hyponatremia in Infectious Diseases-A Literature Review.International journal of environmental research and public health · 2020Review
- A rare etiology behind isolated lateral rectus palsy: Scrub typhus.Journal of family medicine and primary care · 2020Article
- Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionScrub typhus is an acute febrile illness caused by
objectiveTo assess the clinical spectrum and complications of scrub typhus infection at a tertiary care centre in North India. MATERIAL AND
methodsAn observational study was conducted on patients >14 years old with acute febrile illness >7 days duration, admitted indoor from emergency department, from July to November 2017. Suspected cases were tested for specific IgM antibodies against
resultsAmong the 230 patients, screened for scrub typhus infection, 39 (16.95%) came out to be positive. Most common patient complaints were fever followed by cough and breathlessness, myalgia, nausea, vomiting and behavioral abnormality. 15% of patients required inotropic support initially and 48% had oxygen saturation of less than 90% at the time of presentation. Pleural effusion and crepitations were present in 41% of patients. Most common biochemical alterations were: abnormal liver function tests (95%), followed by thrombocytopenia, anemia, abnormal renal function tests, and hyponatremia. 12 patients (30.7%) were shifted to intensive care unit, 8 of which (20.5%) needed invasive mechanical ventilation and 4 patients (10.3%) underwent hemodialysis. Various complications were noted in 89.7% of cases, the most common being ARDS followed by sepsis, acute kidney injury (AKI) and meningitis. The mortality rate in this study was 18%.
conclusionsThis study emphasizes that scrub typhus infection is on a rampant resurgence and it is associated with significant complications. High degree of suspicion as well as development of effective measures to treat, control and prevent is critical to lower the disease burden.
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