ReviewMedicine and pharmacy reports2019
Current treatment modalities of orthodontically induced white spot lesions and their outcome - a literature review.
Review in Medicine and pharmacy reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Randomized Controlled Trial on the Remineralization Agents Used for the Treatment of White Spot Lesions
The Effectiveness of Biomimetic Materials in Preventing Enamel Demineralization During Fixed Appliance Orthodontic Treatment: a Randomized Clinical Trial
Who cites it
15 citing papers in PubMed, 23 citations in OpenAlex.
- Comparative evaluation of four treatments for postorthodontic white spot lesions: a randomized controlled trial.Clinical oral investigations · 2023Trial
- Effect of the caries-protective self-assembling peptide P11-4 on shear bond strength of metal brackets.Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie · 2021Trial
- Impact of self-assembling peptides in remineralisation of artificial early enamel lesions adjacent to orthodontic brackets.Scientific reports · 2020Trial
- The Role of Casein Phosphopeptide-Amorphous Calcium Phosphate (CPP-ACP) in White Spot Lesion Remineralization-A Systematic Review.Journal of functional biomaterials · 2025Review
- Effect of biomimetic tooth mousse and toothpaste on the incidence of white spot lesions during fixed appliance orthodontic treatment: A randomized clinical trial.Journal of Taibah University Medical Sciences · 2025Article
- The effect of antimicrobial peptide-added adhesive resins on shear bond strength and the adhesive remnant index of orthodontic brackets.BMC oral health · 2024Article
- Article
- Candida albicans enriched in orthodontic derived white spot lesions and shaped focal supragingival bacteriome.Frontiers in microbiology · 2023Article
- Formulation and characterization of experimental orthodontic adhesive containing antibacterial dimethacrylate DABCO monomers: An in vitro study.International orthodontics · 2022Article
- White Spots Prevalence and Tooth Brush Habits during Orthodontic Treatment.Healthcare (Basel, Switzerland) · 2022Article
- Microinvasive esthetic approach for deep enamel white spot lesion.Dental research journal · 2022Article
- Oral Health Self-Management Ability and Its Influencing Factors among Adolescents with Fixed Orthodontics in China: A Mixed Methods Study.Disease markers · 2022Article
- Antibacterial and white spot lesions preventive effect of an orthodontic resin modified with silver-nanoparticles.Journal of clinical and experimental dentistry · 2021Article
- Article
- Comparison of the effects of toothpastes containing nanohydroxyapatite and fluoride on white spot lesions in orthodontic patients: A randomized clinical trial.Dental research journalArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionWhite spot lesion is a demineralization of the enamel that appears as a white spot on the surfaces of the tooth. The cause of this spot is determined by the activity of the bacterial plaque and it represents the initial stage of a carious lesion. This lesion is a common side effect for patients with fixed orthodontic appliances mainly because of the brackets' position that favors the accumulation of plaque that ultimately leads to the formation of the white spot.
methodsWe conducted a search on a single database, PubMed. "Orthodontic", "white spot lesions", "enamel demineralization treatment" and "remineralization" were the search terms used. We found 324 articles, but we took in consideration only the ones from the last 10 years, which resulted in 223 articles.
resultsThe first step after research was article selection: first by scrutinizing the title and secondly by reviewing the abstracts or full texts. The exclusion criteria were: meta-analysis, reviews, original articles regarding prevention of white spot lesions and their prevalence or incidence. We included the articles that seemed relevant for the treatment of white spot lesions, made either on extracted teeth either on orthodontic patients. We found 75 articles to be eligible for this research and we eliminated 5 because of the lack of an abstract or full text and a further 22 were rejected because they did not fit the aforementioned criteria.
conclusionAlthough some traditional methods for the treatment of white spot lesions seem to have undesirable results, nowadays with new technologies and thorough investigations in nanotechnology, the eradication of the lesion appears to be short term.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.