SynthesisBJS open2019
Systematic review of therapeutic nipple-sparing
Synthesis in BJS open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Oncological, surgical, and cosmetic outcomes of endoscopic versus conventional nipple-sparing mastectomy: meta-analysis.BJS open · 2025Pooled it
- Risk factors for residual fibroglandular breast tissue following a mastectomy - an overview and retrospective cohort study.BMC cancer · 2024Pooled it
- Outcomes of robotic nipple-sparing mastectomy versus conventional nipple-sparing mastectomy in women with breast cancer: a systematic review and meta-analysis.Journal of robotic surgery · 2023Pooled it
- Curative effect of immediate reconstruction after neoadjuvant chemotherapy for breast cancer: a systematic review and meta-analysis.Frontiers in oncology · 2023Pooled it
- Comparison of mastectomy and breast reconstruction outcomes using low thermal dissection versus traditional electrocautery: a blinded randomized trial.Breast cancer research and treatment · 2021Trial
- Article
- Local recurrence in nipple-sparing mastectomy without intraoperative radiotherapy (IORT) in breast cancer.Gland surgery · 2026Article
- The Role of Indocyanine Green Angiography and Axillary Reverse Mapping in Breast Reconstruction Surgery.Journal of clinical medicine · 2026Article
- Breast reconstructive considerations in patients at increased risk for radiodermatitis: combined checkpoint inhibitor and PARP inhibitor therapy.AME case reports · 2026Article
- Long-term oncologic outcomes of minimal access (endoscopic or Robotic Assisted) nipple-sparing mastectomy compared with conventional approach in breast cancer - a propensity score matching analysis.International journal of surgery (London, England) · 2025Article
- Patient-reported outcomes following various incision techniques in breast reconstruction: an observational cohort study in China.Journal of cancer research and clinical oncology · 2025Observational
- Oncoplastic Nipple-Sparing Mastectomy and Immediate Reconstruction in Non-ideal Candidates.Cureus · 2025Article
- Techniques for Success in Nipple-Sparing Mastectomy and Immediate Reconstruction.Journal of clinical medicine · 2025Review
- Effects of breast size on breast reconstruction in BRCA mutation carriers and genetic high-risk patients after bilateral mastectomy.Breast cancer (Tokyo, Japan) · 2025Article
- Comparison of nipple sparing and skin sparing mastectomy with immediate reconstruction based on patient reported outcomes.Scientific reports · 2025Article
- Article
- Staged Nipple Delay Procedure Expands Candidacy for Nipple-Sparing Mastectomy.Annals of surgical oncology · 2025Article
- The Impact of Complication Timing on the Outcomes of Implant-based Breast Reconstruction.Plastic and reconstructive surgery. Global open · 2024Article
- A BRILLIANT-BRCA study: residual breast tissue after mastectomy and reconstruction.Breast cancer research and treatment · 2024Article
- Impact of Mastectomy Flap Necrosis on Patient-Reported Quality-of-Life Measures After Nipple-Sparing Mastectomy: A Preliminary Analysis.Annals of surgical oncology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The use of nipple-sparing mastectomy (NSM) is increasing, despite unproven oncological safety in the therapeutic setting. The aim of this systematic review was to determine the safety and efficacy of NSM compared with skin-sparing mastectomy (SSM). Methods: A literature search of all original studies including RCTs, cohort studies and case-control studies comparing women undergoing therapeutic NSM or SSM for breast cancer was undertaken. Primary outcomes were oncological outcomes; secondary outcomes were clinical, aesthetic, patient-reported and quality-of-life outcomes. Data analysis was undertaken to explore the relationship between NSM and SSM, and preselected outcomes. Heterogeneity was assessed using the Cochrane tests. Results: A total of 690 articles were identified, of which 14 were included. There was no statistically significant difference in 5-year disease-free survival and mortality for NSM and SSM groups, where data were available. Local recurrence rates were also similar for NSM and SSM (3·9 Conclusion: In carefully selected cases, NSM is a viable choice for women with breast cancer who need to have a mastectomy. More research is needed to help further refine which surgical approaches to NSM optimize outcomes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.