Evidence map›Paper›PMID 30956991›Full record

ArticleJournal of diabetes research2019

Oral LPS Dosing Induces Local Immunological Changes in the Pancreatic Lymph Nodes in Mice.

Pernille Kihl, Lukasz Krych, Ling Deng, Anna Overgaard Kildemoes, Ann Laigaard, Lars Hestbjerg Hansen, Camilla Hartmann Friis Hansen, Karsten Buschard, Dennis Sandris Nielsen, Axel Kornerup Hansen

Open access · goldAbstract read
In one paragraph

Article in Journal of diabetes research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
  3. The biofunction ofMicrobiome research reports · 2024
    Review
  4. Article
  5. Review
  6. The Role of the Gut Microbiota in the Pathogenesis of Diabetes.International journal of molecular sciences · 2022
    Review
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Pernille KihlDepartment of Veterinary and Animal Sciences, University of Copenhagen, Grønnegårdsvej 15, 1870 Frederiksberg C, Denmark.
Lukasz KrychDepartment of Food Science, University of Copenhagen, Rolighedsvej 26, 1958 Frederiksberg C, Denmark.
Ling DengDepartment of Food Science, University of Copenhagen, Rolighedsvej 26, 1958 Frederiksberg C, Denmark.
Anna Overgaard KildemoesDepartment of Veterinary and Animal Sciences, University of Copenhagen, Grønnegårdsvej 15, 1870 Frederiksberg C, Denmark.
Ann LaigaardDepartment of Veterinary and Animal Sciences, University of Copenhagen, Grønnegårdsvej 15, 1870 Frederiksberg C, Denmark.
Lars Hestbjerg HansenDepartment of Environmental Sciences, University of Århus, Frederiksborgvej 399, 4000 Roskilde, Denmark.
Camilla Hartmann Friis HansenDepartment of Veterinary and Animal Sciences, University of Copenhagen, Grønnegårdsvej 15, 1870 Frederiksberg C, Denmark.
Karsten BuschardBartholin Institute, Rigshospitalet, Ole Måløesvej 5, 2200 Copenhagen N, Denmark.ORCID 0000-0002-0126-7423
Dennis Sandris NielsenDepartment of Food Science, University of Copenhagen, Rolighedsvej 26, 1958 Frederiksberg C, Denmark.ORCID 0000-0001-8121-1114
Axel Kornerup HansenDepartment of Veterinary and Animal Sciences, University of Copenhagen, Grønnegårdsvej 15, 1870 Frederiksberg C, Denmark.ORCID 0000-0003-1575-2507
University of Copenhagen · DKRigshospitalet · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lacking the initial contact between the immune system and microbial-associated molecular patterns (MAMPs), such as lipopolysaccharides (LPS), early in life, may be regarded as one of the causal factors of the increasing global increase in the incidence of autoimmune diseases, such as type 1 diabetes (T1D). Previously, a reduced incidence of T1D accompanied by dramatically increased abundances of both the mucin-metabolising bacterium

Indexed as

Administration, OralAnimalsCytokinesDiabetes Mellitus, Type 1Drug Administration ScheduleEscherichia coliFemaleGastrointestinal MicrobiomeIncidenceLipopolysaccharidesLymph NodesMaleMiceMice, Inbred C57BLMice, Inbred NODPancreasCytokinesLipopolysaccharides

Identifiers

PMID30956991
PMCPMC6431374
OpenAlexW2918666218

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.