Evidence map›Paper›PMID 30956778›Full record

ArticleOncotarget2019

Specific allelic variants of SNPs in the

Marcus Bauer, Eva Johanna Kantelhardt, Thorsten Stiewe, Andrea Nist, Marco Mernberger, Katharina Politt, Volker Hanf, Tilmann Lantzsch, Christoph Uleer, Susanne Peschel and 8 more

Open access · diamondAbstract read
In one paragraph

Article in Oncotarget, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Observational
  2. Review
  3. Article
  4. Impact ofInternational journal of molecular medicine · 2022
    Article
  5. Article
  6. Associations ofJournal of clinical medicine · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 8 institutions in 1 country.

Marcus BauerInstitute of Pathology, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany.
Eva Johanna KantelhardtDepartment of Gynaecology, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany.
Thorsten StieweInstitute of Molecular Oncology, Universities of Giessen and Marburg Lung Center, German Center for Lung Research (DZL), Marburg, Germany.
Andrea NistInstitute of Molecular Oncology, Universities of Giessen and Marburg Lung Center, German Center for Lung Research (DZL), Marburg, Germany.
Marco MernbergerInstitute of Molecular Oncology, Universities of Giessen and Marburg Lung Center, German Center for Lung Research (DZL), Marburg, Germany.
Katharina PolittInstitute of Molecular Oncology, Universities of Giessen and Marburg Lung Center, German Center for Lung Research (DZL), Marburg, Germany.
Volker HanfDepartment of Gynaecology, Hospital Fuerth, Fuerth, Germany.
Tilmann LantzschDepartment of Gynaecology, Hospital St. Elisabeth and St. Barbara, Halle (Saale), Germany.
Christoph UleerOnkologische Praxis Uleer, Hildesheim, Germany.
Susanne PeschelDepartment of Gynaecology, St. Bernward Hospital, Hildesheim, Germany.
Jutta JohnDepartment of Gynaecology, Helios Hospital Hildesheim, Hildesheim, Germany.
Jörg BuchmannInstitute of Pathology, Hospital Martha-Maria, Halle (Saale), Germany.
Edith WeigertInstitute of Pathology, Hospital Fuerth, Fuerth, Germany.
Karl-Friedrich BürrigInstitute of Pathology Hildesheim, Hildesheim, Germany.
Claudia WickenhauserInstitute of Pathology, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany.
Christoph ThomssenDepartment of Gynaecology, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany.
Frank BartelInstitute of Pathology, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany.
Martina VetterDepartment of Gynaecology, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany.
Martin Luther University Halle-Wittenberg · DEGerman Center for Lung Research · DEKlinikum Fulda · DEUniversity of Hildesheim · DEKrankenhaus St. Elisabeth und St. Barbara · DEMartha-Maria Hospital · DESt. Bernward Krankenhaus · DEUniversities of Giessen and Marburg Lung Center · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGenetic factors play a substantial role in breast cancer etiology. Genes encoding proteins that have key functions in the DNA damage response, such as p53 and its inhibitors MDM2 and MDMX, are most likely candidates to harbor allelic variants that influence breast cancer susceptibility. The aim of our study was to comprehensively analyze the impact of SNPs in the

methodsIn specimen from 815 breast cancer patients, five SNPs within the selected genes were analyzed:

resultsThe homozygous C-allele of

conclusionsWe showed that SNPs in the

Indexed as

breast cancermutationp53single nucleotide polymorphismtumor suppression

Identifiers

PMID30956778
PMCPMC6443004
OpenAlexW2922437764

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.