Evidence map›Paper›PMID 30956771›Full record

ArticleOncotarget2019

ABL kinase inhibition sensitizes primary lung adenocarcinomas to chemotherapy by promoting tumor cell differentiation.

Aaditya Khatri, Jing Jin Gu, Courtney M McKernan, Xia Xu, Ann Marie Pendergast

Erratum issuedOpen access · diamondAbstract read
In one paragraph

Article in Oncotarget, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. YB-1 activating cascades as potential targets in KRAS-mutated tumors.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2023
    Review
  3. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Aaditya KhatriDepartment of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC, USA.
Jing Jin GuDepartment of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC, USA.
Courtney M McKernanDepartment of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC, USA.
Xia XuDepartment of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC, USA.
Ann Marie PendergastDepartment of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC, USA.
Duke Medical Center · USDuke University Hospital · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007171 · NIGMS · DUKE UNIVERSITY · PI KONTOS, CHRISTOPHER D · 1985 to 2021
$31.2M
Novel target for therapy refractory lung tumorsR01CA195549 · NCI · DUKE UNIVERSITY · PI PENDERGAST, ANN MARIE · 2015 to 2019
$1.8M
The Role of Abl Kinase Signaling in HER2+ Breast Cancer Brain MetastasisF31CA224952 · NCI · DUKE UNIVERSITY · PI MCKERNAN, COURTNEY MICHELLE · 2018 to 2020
$118k
Regulation of cell permeability by Abl kinases and implications for the treating of acute lung injuryF30HL126448 · NHLBI · DUKE UNIVERSITY · PI KHATRI, AADITYA · 2015 to 2017
$117k
NCI NIH HHS F31 CA224952NCI NIH HHS R01 CA195549NHLBI NIH HHS F30 HL126448NIGMS NIH HHS T32 GM007171
6 · The paper itself

Abstract

Lung cancer is the leading cause of cancer mortality in the United States, with an overall five-year survival rate of ~16%. Non-small cell lung cancer (NSCLC) accounts for ~80% of all lung cancer cases, and the majority (40%) of these are adenocarcinomas. Loss of function point mutations in

Indexed as

ABL kinasesdifferentiationdocetaxellung adenocarcinomaYAP1

Identifiers

PMID30956771
PMCPMC6443011
OpenAlexW2921152722

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.