Evidence map›Paper›PMID 30956763›Full record

ArticleOncotarget2019

Biomarker results from a phase II study of MEK1/2 inhibitor binimetinib (MEK162) in patients with advanced

Carla M L van Herpen, Sanjiv S Agarwala, Axel Hauschild, Carola Berking, J Thaddeus Beck, Dirk Schadendorf, Rob Jansen, Paola Queirolo, Paolo A Ascierto, Christian U Blank and 7 more

Open access · diamondAbstract read
In one paragraph

Article in Oncotarget, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
  6. Targeted Therapy for Melanomas Without BRAF V600 Mutations.Current treatment options in oncology · 2022
    Review
  7. The Biology of Classic Hairy Cell Leukemia.International journal of molecular sciences · 2021
    Review
  8. Article
  9. Review
  10. Article
  11. A Review of the Molecular Pathways Involved in Resistance to BRAF Inhibitors in Patients with Advanced-Stage Melanoma.Medical science monitor : international medical journal of experimental and clinical research · 2020
    Review
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 15 institutions in 6 countries.

Carla M L van HerpenDepartment of Medical Oncology, Radboud University Medical Center, Nijmegen, The Netherlands.
Sanjiv S AgarwalaDepartment of Medical Oncology and Hematology, St. Luke's University Health Network, Bethlehem, PA, USA.
Axel HauschildDepartment of Dermatology, University Hospital Schleswig-Holstein, Kiel, Germany.
Carola BerkingDepartment of Dermatology, University Hospital of Munich (LMU), Munich, Germany.
J Thaddeus BeckDepartment of Oncology, Highlands Oncology Group, Fayetteville, AR, USA.
Dirk SchadendorfDepartment of Dermatology, University Hospital Essen, Essen, Germany.
Rob JansenDepartment of Medical Oncology, Maastricht University Medical Center, Maastricht, The Netherlands.
Paola QueiroloDepartment of Medical Oncology, IRCCS San Martino, IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy.
Paolo A AsciertoUnit of Melanoma, Cancer Immunotherapy and Innovative Therapy, Istituto Nazionale Tumori Fondazione Pascale, Naples, Italy.
Christian U BlankDepartment of Medical Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Michael C HeinrichDepartment of Medicine, Veterans Administration Portland Health Care System and Oregon Health and Science University Knight Cancer Institute, Portland, OR, USA.
Rupam R PalBiostatistics, Novartis Healthcare Private Limited, Hyderabad, India.
Adnan DertiDepartment of Translational Oncology, Novartis Institutes for BioMedical Research, Cambridge, MA, USA.
Victor AntonaDepartment of Translational Oncology, Novartis Institutes for BioMedical Research, Basel, Switzerland.
Heidi NauwelaertsDepartment of Translational Oncology, Novartis Institutes for BioMedical Research, Basel, Switzerland.
Angela ZubelDepartment of Translational Oncology, Novartis Institutes for BioMedical Research, Basel, Switzerland.
Reinhard DummerDepartment of Dermatology, University Hospital Zurich, Zurich, Switzerland.
Novartis Institutes for BioMedical ResearchAlleanza Contro il Cancro · ITEssen University Hospital · DEHighlands Oncology Group · USIstituto Nazionale Tumori IRCCS "Fondazione G. Pascale" · ITLudwig-Maximilians-Universität München · DEMaastricht University · NLNovartis (India) · INNovartis (Switzerland) · CHRadboud University Medical Center · NLSt. Luke's University Health Network · USThe Netherlands Cancer Institute · NLUniversity Hospital of Zurich · CHUniversity Hospital Schleswig-Holstein · DEVA Portland Health Care System · US

Funding

Regulation of oncogenic KIT by LMTK3I01BX000338 · VA · PORTLAND VA MEDICAL CENTER · PI HEINRICH, MICHAEL C · 2009 to 2019
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BLRD VA I01 BX000338BLRD VA I01 BX005358
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

binimetinibbiomarkerMEK inhibitormelanomaphase II

Identifiers

PMID30956763
PMCPMC6442999
OpenAlexW2919427775

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.