ArticleOncotarget2019
Genetic interaction analysis among oncogenesis-related genes revealed novel genes and networks in lung cancer development.
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Article in Oncotarget, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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19citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 14% of its field
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Cross-ancestry genome-wide meta-analysis of 61,047 cases and 947,237 controls identifies new susceptibility loci contributing to lung cancer.Nature genetics · 2022Pooled it
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- Enhanced response to dabrafenib plus trametinib in a patient withFrontiers in oncology · 2025Article
- Sex differences in the tumor promoting effects of tobacco smoke in a cRaf transgenic lung cancer disease model.Archives of toxicology · 2024Article
- Candidate pathway analysis of surfactant proteins identifies CTSH and SFTA2 that influences lung cancer risk.Human molecular genetics · 2023Article
- The blood proteome of imminent lung cancer diagnosis.Nature communications · 2023Article
- Genetic variants of cancer‑associated genes analyzed using next‑generation sequencing in small sporadic vestibular schwannomas.Oncology letters · 2023Article
- Concurrent outcomes from multiple approaches of epistasis analysis for human body mass index associated loci provide insights into obesity biology.Scientific reports · 2022Article
- Identification of ITPR1 as a Hub Gene of Group 3 Medulloblastoma and Coregulated Genes with Potential Prognostic Values.Journal of molecular neuroscience : MN · 2022Article
- Molecular Pathology of Lung Cancer.Cold Spring Harbor perspectives in medicine · 2022Review
- Gene-gene interaction of AhRwith and within the Wntcascade affects susceptibility to lung cancer.European journal of medical research · 2022Article
- Migrations of cancer cells through the lens of phylogenetic biogeography.Scientific reports · 2021Article
- Genetic interactions effects for cancer disease identification using computational models: a review.Medical & biological engineering & computing · 2021Review
- Rare deleterious germline variants and risk of lung cancer.NPJ precision oncology · 2021Article
- Combination of 35-Gene Mutation Profile and Radiotherapy Dosimetry Predicts the Therapeutic Outcome of Definitive Chemoradiation in Patients With Esophageal Squamous Cell Carcinoma.Frontiers in oncology · 2021Article
- Unique genomic features and prognostic value of COSMIC mutational signature 4 in lung adenocarcinoma and lung squamous cell carcinoma.Annals of translational medicine · 2020Article
- TSPAN8 and distant metastasis of nasopharyngeal carcinoma cells.Annals of translational medicine · 2020Article
- Knockdown of SLCO4C1 inhibits cell proliferation and metastasis in endometrial cancer through inactivating the PI3K/Akt signaling pathway.Oncology reports · 2020Article
Corrections and comments
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Authors and funding
80 authors at 20 institutions in 19 countries.
Yafang LiBaylor College of Medicine, Houston, TX, USA.
Xiangjun XiaoBaylor College of Medicine, Houston, TX, USA.
Yohan BosséLaval University, Quebec, QC, Canada.
Olga GorlovaDepartment of Biomedical Data Science, Dartmouth College, Hanover, NH, USA.
Ivan GorlovDepartment of Biomedical Data Science, Dartmouth College, Hanover, NH, USA.
Younghun HanBaylor College of Medicine, Houston, TX, USA.
Jinyoung ByunBaylor College of Medicine, Houston, TX, USA.
Natasha LeighlUniversity Health Network, The Princess Margaret Cancer Centre, Toronto, CA, USA.
Jakob S JohansenDepartment of Oncology, Herlev and Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark.
Matt BarnettFred Hutchinson Cancer Research Center, Seattle, WA, USA.
Chu ChenFred Hutchinson Cancer Research Center, Seattle, WA, USA.
Gary GoodmanSwedish Medical Group, Seattle, WA, USA.
Angela CoxDepartment of Oncology, University of Sheffield, Sheffield, UK.
Fiona TaylorDepartment of Oncology, University of Sheffield, Sheffield, UK.
Penella WollDepartment of Oncology, University of Sheffield, Sheffield, UK.
H Erich WichmannResearch Unit of Molecular Epidemiology, Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Judith ManzResearch Unit of Molecular Epidemiology, Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Thomas MuleyThoraxklinik at University Hospital Heidelberg, Translational Lung Research Center Heidelberg (TLRC-H), Heidelberg, Germany.
Angela RischTranslational Lung Research Center Heidelberg (TLRC-H), Heidelberg, Germany.
Albert RosenbergerDepartment of Genetic Epidemiology, University Medical Center, Georg-August-University Göttingen, Göttingen, Germany.
Jiali HanIndiana University, Bloomington, IN, USA.
Katherine SiminovitchUniversity of Toronto, Toronto, ON, Canada.
Susanne M ArnoldUniversity of Kentucky, Markey Cancer Center, Lexington, KY, USA.
Eric B HauraDepartment of Thoracic Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Ciprian BolcaInstitute of Pneumology "Marius Nasta", Bucharest, Romania.
Ivana HolcatovaFaculty of Medicine, University of Ostrava, Ostrava, Czech Republic.
Vladimir JanoutFaculty of Medicine, University of Ostrava, Ostrava, Czech Republic.
Milica KonticClinical Center of Serbia, School of Medicine, University of Belgrade, Belgrade, Serbia.
Jolanta LissowskaM. Sklodowska-Curie Cancer Center, Institute of Oncology, Warsaw, Poland.
Anush MukeriaDepartment of Epidemiology and Prevention, N.N. Blokhin Russian Cancer Research Center, Moscow, Russian Federation.
Simona OgnjanovicInternational Organization for Cancer Prevention and Research, Belgrade, Serbia.
Tadeusz M OrlowskiDepartment of Surgery, National Tuberculosis and Lung Diseases Research Institute, Warsaw, Poland.
Ghislaine SceloInternational Agency for Research on Cancer, World Health Organization, Lyon, France.
Beata SwiatkowskaNofer Institute of Occupational Medicine, Department of Environmental Epidemiology, Lodz, Poland.
David ZaridzeDepartment of Epidemiology and Prevention, N.N. Blokhin Russian Cancer Research Center, Moscow, Russian Federation.
Per BakkeDepartment of Clinical Science, University of Bergen, Bergen, Norway.
Vidar SkaugNational Institute of Occupational Health, Oslo, Norway.
Shanbeh ZienolddinyNational Institute of Occupational Health, Oslo, Norway.
Eric J DuellUnit of Nutrition and Cancer, Catalan Institute of Oncology (ICO-IDIBELL), Barcelona, Spain.
Lesley M ButlerUniversity of Pittsburgh Cancer Institute, Pittsburgh, PA, USA.
Richard HoulstonThe Institute of Cancer Research, London, UK.
María Soler ArtigasDepartment of Health Sciences, Genetic Epidemiology Group, University of Leicester, Leicester, UK.
Kjell GrankvistDepartment of Medical Biosciences, Umeå University, Umeå, Sweden.
Mikael JohanssonDepartment of Radiation Sciences, Umeå University, Umeå, Sweden.
Frances A ShepherdPrincess Margaret Cancer Centre, Toronto, ON, Canada.
Michael W MarcusInstitute of Translational Medicine, University of Liverpool, Liverpool, UK.
Hans BrunnströmDepartment of Pathology, Lund University, Lund, Sweden.
Jonas ManjerFaculty of Medicine, Lund University, Lund, Sweden.
Olle MelanderFaculty of Medicine, Lund University, Lund, Sweden.
David C MullerSchool of Public Health, St. Mary's Campus, Imperial College London, London, UK.
Kim OvervadSection for Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark.
Antonia TrichopoulouHellenic Health Foundation, Athens, Greece.
Rosario TuminoMolecular and Nutritional Epidemiology Unit CSPO (Cancer Research and Prevention Centre), Scientific Institute of Tuscany, Florence, Italy.
Geoffrey LiuLunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, University of Toronto, Toronto, Canada.
Stig E BojesenDepartment of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Denmark.
Xifeng WuDepartment of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Loic Le MarchandEpidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA.
Demetrios AlbanesDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Heike BickeböllerDepartment of Genetic Epidemiology, University Medical Center, Georg-August-University Göttingen, Göttingen, Germany.
Melinda C AldrichDepartment of Thoracic Surgery, Division of Epidemiology, Vanderbilt University Medical Center, Nashville, TN, USA.
William S BushDepartment of Epidemiology and Biostatistics, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Adonina TardonIUOPA, University of Oviedo and CIBERESP, Faculty of Medicine, Campus del Cristo s/n, Oviedo, Spain.
Gad RennertClalit National Cancer Control Center at Carmel Medical Center and Technion Faculty of Medicine, Haifa, Israel.
M Dawn TeareSchool of Health and Related Research, University of Sheffield, Sheffield, UK.
John K FieldInstitute of Translational Medicine, University of Liverpool, Liverpool, UK.
Lambertus A KiemeneyRadboud University Medical Center, Nijmegen, The Netherlands.
Philip LazarusDepartment of Pharmaceutical Sciences, College of Pharmacy, Washington State University, Spokane, WA, USA.
Aage HaugenNational Institute of Occupational Health, Oslo, Norway.
Stephen LamBritish Columbia Cancer Agency, Vancouver, Canada.
Matthew B SchabathDepartment of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Angeline S AndrewDepartment of Epidemiology, Geisel School of Medicine, Hanover, NH, USA.
Pier Alberto BertazziDepartment of Preventive Medicine, IRCCS Foundation Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Angela C PesatoriDepartment of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
David C ChristianiDepartment of Epidemiology, Program in Molecular and Genetic Epidemiology Harvard School of Public Health, Boston, MA, USA.
Neil CaporasoDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Mattias JohanssonLunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, University of Toronto, Toronto, Canada.
James D McKayLunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, University of Toronto, Toronto, Canada.
Paul BrennanLunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, University of Toronto, Toronto, Canada.
Rayjean J HungInternational Agency for Research on Cancer, World Health Organization, Lyon, France.
Christopher I AmosBiomedical Data Science Department, Dartmouth College, Hanover, NH, USA.
Baylor College of Medicine · USDartmouth College · USUniversity of Sheffield · GBLund University · SENational Institute of Occupational Health · NOCentre international de recherche sur le cancer · FRFred Hutch Cancer Center · USHelmholtz Zentrum München · DEMoffitt Cancer Center · USMount Sinai Hospital · CANational Cancer Institute · USRussian Cancer Research Center NN Blokhin · RUUmeå University · SEUniversity of Göttingen · DEUniversity of Liverpool · GBUniversity of Ostrava · CZUniversity of Toronto · CAAarhus University · DKBC Cancer Agency · CACarmel Medical Center · IL
Funding
TRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI Christine O'Connell · 1998 to 2026
$93.5MTranslating Molecular and Clinical Data to Population Lung Cancer Risk AssessmentU19CA203654 · NCI · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Christopher I. Amos, Rayjean J. Hung · 2017 to 2026
$23.7MSPORE in Lung CancerP50CA119997 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI GABRILOVICH, DMITRY I · 2008 to 2012
$11.0MStatistical Methods for Analysis of Massive Genetic and Genomic Data in Cancer ResearchR35CA197449 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI XIHONG LIN · 2015 to 2026
$10.9MInfrastructure Support and Pilot Tissue Collection for the CARET BiorepositoryU01CA167462 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI NEUHOUSER, MARIAN L · 2018 to 2022
$2.9MGenetic interaction analysis involving oncogenesis-related genes in lung cancerR21CA235464 · NCI · BAYLOR COLLEGE OF MEDICINE · PI LI, YAFANG · 2019 to 2020
$380kNCI NIH HHS P30 CA076292NCI NIH HHS P50 CA119997NCI NIH HHS R21 CA235464NCI NIH HHS R35 CA197449NCI NIH HHS U01 CA167462NCI NIH HHS U19 CA203654World Health Organization 001
Abstract
The development of cancer is driven by the accumulation of many oncogenesis-related genetic alterations and tumorigenesis is triggered by complex networks of involved genes rather than independent actions. To explore the epistasis existing among oncogenesis-related genes in lung cancer development, we conducted pairwise genetic interaction analyses among 35,031 SNPs from 2027 oncogenesis-related genes. The genotypes from three independent genome-wide association studies including a total of 24,037 lung cancer patients and 20,401 healthy controls with Caucasian ancestry were analyzed in the study. Using a two-stage study design including discovery and replication studies, and stringent Bonferroni correction for multiple statistical analysis, we identified significant genetic interactions between SNPs in
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epistasisfunctional annotationlung canceroncogenesis
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