Evidence map›Paper›PMID 30956747›Full record

ArticleThe annals of applied statistics2017

A STATISTICAL FRAMEWORK FOR DATA INTEGRATION THROUGH GRAPHICAL MODELS WITH APPLICATION TO CANCER GENOMICS.

Yuping Zhang, Zhengqing Ouyang, Hongyu Zhao

Abstract read
In one paragraph

Article in The annals of applied statistics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Integrative Analysis of Multimodal Omics Data.Annual review of statistics and its application · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Yuping ZhangDEPARTMENT OF STATISTICS, INSTITUTE FOR SYSTEMS GENOMICS, CENTER FOR QUANTITATIVE MEDICINE, INSTITUTE FOR COLLABORATION ON HEALTH, INTERVENTION, AND POLICY, THE CONNECTICUT INSTITUTE FOR THE BRAIN AND COGNITIVE SCIENCES, UNIVERSITY OF CONNECTICUT, STORRS, CONNECTICUT 06269, USA, yuping.zhang@uconn.edu.
Zhengqing OuyangTHE JACKSON LABORATORY FOR GENOMIC MEDICINE, DEPARTMENT OF BIOMEDICAL ENGINEERING, DEPARTMENT OF GENETICS AND GENOME SCIENCES, INSTITUTE FOR SYSTEMS GENOMICS, UNIVERSITY OF CONNECTICUT, FARMINGTON, CONNECTICUT 06030, USA, zhengqing.ouyang@jax.org.
Hongyu ZhaoDEPARTMENT OF BIOSTATISTICS, YALE SCHOOL OF PUBLIC HEALTH, NEW HAVEN, CONNECTICUT 06510, USA, hongyu.zhao@yale.edu.

Funding

Yale Study Support Suite (YES3): Dashboard and Web Portal Software Supporting Research Workflow through integrated, customizable REDCap External ModulesP30AG021342 · NIA · YALE UNIVERSITY · PI Denise Esserman · 2002 to 2026
$37.9M
Clinical Study of PHY906, a Novel Chinese Herbal Medicine, as a Modulator of IrinP01CA154295 · NCI · YALE UNIVERSITY · PI CHENG, YUNG-CHI · 2011 to 2016
$6.4M
STATISTICAL METHODS TO MAP GENES FOR COMPLEX TRAITSR01GM059507 · NIGMS · YALE UNIVERSITY · PI ZHAO, HONGYU · 1999 to 2013
$3.6M
NCI NIH HHS P01 CA154295NIA NIH HHS P30 AG021342NIGMS NIH HHS R01 GM059507
6 · The paper itself

Abstract

Recent advances in high-throughput biotechnologies have generated var-ious types of genetic, genomic, epigenetic, transcriptomic and proteomic data across different biological conditions. It is likely that integrating data from diverse experiments may lead to a more unified and global view of biolog-ical systems and complex diseases. We present a coherent statistical frame-work for integrating various types of data from distinct but related biological conditions through graphical models. Specifically, our statistical framework is designed for modeling multiple networks with shared regulatory mech-anisms from heterogeneous high-dimensional datasets. The performance of our approach is illustrated through simulations and its applications to cancer genomics.

Indexed as

Cancer genomicsdata integrationgraphical models

Identifiers

PMID30956747
PMCPMC6447291

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.