ArticleStructure (London, England : 1993)2019
Altered Domain Structure of the Prion Protein Caused by Cu
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Article in Structure (London, England : 1993), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21citing papers in PubMed
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Who cites it
21 citing papers in PubMed.
- Tackling cuproptosis: from metabolic rewiring to therapeutic exploitation in cancer.Cellular & molecular immunology · 2026Review
- Pathological and Functional Brain Amyloids: A New Concept Explaining the Differences.International journal of molecular sciences · 2025Review
- Segmental Isotope Labeling of the Prion Protein: Identification of a Key Residue for Copper-Mediated Interdomain Structure.ACS chemical biology · 2025Article
- Soluble N-terminal region of prion protein causes rapid neurodegeneration in prion disease.Science advances · 2025Article
- Prion protein promotes copper toxicity in Wilson disease.Nature communications · 2025Article
- Prion Protein Endoproteolysis: Cleavage Sites, Mechanisms and Connections to Prion Disease.Journal of neurochemistry · 2025Review
- Cellular Prion Protein Conformational Shift after Liquid-Liquid Phase Separation Regulated by a Polymeric Antagonist and Mutations.Journal of the American Chemical Society · 2024Article
- Abnormal synaptic architecture in iPSC-derived neurons from a multi-generational family with genetic Creutzfeldt-Jakob disease.Stem cell reports · 2024Article
- Mechanisms of prion-induced toxicity.Cell and tissue research · 2023Review
- Structural and dynamical determinants of a β-sheet-enriched intermediate involved in amyloid fibrillar assembly of human prion protein.Chemical science · 2022Article
- Prion protein with a mutant N-terminal octarepeat region undergoes cobalamin-dependent assembly into high-molecular weight complexes.The Journal of biological chemistry · 2022Article
- EPR of copper centers in the prion protein.Methods in enzymology · 2022Article
- Zn(II) binding causes interdomain changes in the structure and flexibility of the human prion protein.Scientific reports · 2021Article
- Structural Proteomics Methods to Interrogate the Conformations and Dynamics of Intrinsically Disordered Proteins.Frontiers in chemistry · 2021Review
- Multimodal small-molecule screening for human prion protein binders.The Journal of biological chemistry · 2020Article
- Both N-Terminal and C-Terminal Histidine Residues of the Prion Protein Are Essential for Copper Coordination and Neuroprotective Self-Regulation.Journal of molecular biology · 2020Article
- Intrinsic toxicity of the cellular prion protein is regulated by its conserved central region.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020Article
- Deciphering Copper Coordination in the Mammalian Prion Protein Amyloidogenic Domain.Biophysical journal · 2020Article
- Structural Features of Heparin and Its Interactions With Cellular Prion Protein Measured by Surface Plasmon Resonance.Frontiers in molecular biosciences · 2020Article
- Aggregation of biologically important peptides and proteins: inhibition or acceleration depending on protein and metal ion concentrations.RSC advances · 2019Review
Corrections and comments
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Authors and funding
13 authors.
Alex J McDonaldDepartment of Biochemistry, Boston University School of Medicine, Boston, MA 02118, USA.
Deborah R LeonDepartment of Biochemistry, Boston University School of Medicine, Boston, MA 02118, USA; Center for Biomedical Mass Spectrometry, Boston University School of Medicine, Boston, MA 02118, USA.
Kathleen A MarkhamDepartment of Chemistry and Biochemistry, University of California, Santa Cruz, Santa Cruz, CA 95064, USA.
Bei WuDepartment of Biochemistry, Boston University School of Medicine, Boston, MA 02118, USA.
Christian F HeckendorfDepartment of Biochemistry, Boston University School of Medicine, Boston, MA 02118, USA; Center for Biomedical Mass Spectrometry, Boston University School of Medicine, Boston, MA 02118, USA.
Kevin SchillingDepartment of Chemistry and Biochemistry, University of California, Santa Cruz, Santa Cruz, CA 95064, USA.
Hollis D ShowalterDepartment of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, USA.
Philip C AndrewsDepartment of Biological Chemistry, Department of Chemistry, Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA.
Mark E McCombDepartment of Biochemistry, Boston University School of Medicine, Boston, MA 02118, USA; Center for Biomedical Mass Spectrometry, Boston University School of Medicine, Boston, MA 02118, USA.
M Jake PushieDepartment of Surgery, Division of Neurosurgery, College of Medicine, University of Saskatchewan, Saskatoon, Canada.
Catherine E CostelloDepartment of Biochemistry, Boston University School of Medicine, Boston, MA 02118, USA; Center for Biomedical Mass Spectrometry, Boston University School of Medicine, Boston, MA 02118, USA. Electronic address: cecmsms@bu.edu.
Glenn L MillhauserDepartment of Chemistry and Biochemistry, University of California, Santa Cruz, Santa Cruz, CA 95064, USA. Electronic address: glennm@ucsc.edu.
David A HarrisDepartment of Biochemistry, Boston University School of Medicine, Boston, MA 02118, USA. Electronic address: daharris@bu.edu.
Funding
Mass Spectrometry Resource for Biology and MedicineP41GM104603 · NIGMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI COSTELLO, CATHERINE E. · 2012 to 2017
$10.4MMechanisms of Prion Protein ToxicityR01NS065244 · NINDS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI HARRIS, DAVID A · 2010 to 2025
$8.9MNext-generation Mass Spectrometry Technologies for Integrated Structural Proteomics- RenewalR01GM095832 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI RUOTOLO, BRANDON T · 2011 to 2024
$5.8MMolecular Aspects of Copper Binding to the Prion ProteinR01GM065790 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI MILLHAUSER, GLENN L · 2002 to 2018
$4.5MLegacy Support During Closure of the Mass Spectrometry Resource for Biology and MedicineR24GM134210 · NIGMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI COSTELLO, CATHERINE E. · 2019 to 2021
$2.1M800 MHz NMR Spectrometer and Helium CryoprobeS10OD018455 · OD · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI MILLHAUSER, GLENN L · 2015 to 2015
$2.0MGOLGI MATRIX ASSEMBLY AND DISASSEMBLY IN THE CELL CYCLER01GM105920 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ANDREWS, PHILIP C, WANG, YANZHUANG · 2014 to 2017
$1.9MNew Structural Mass Spectrometry Tools Applied to the Mitochondrial Membrane ProtR01GM105942 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ANDREWS, PHILIP C, RUOTOLO, BRANDON T · 2013 to 2016
$1.4MExploration of Molecular Chaperone Complexes During Active Protein TriageR01GM109896 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ANDREWS, PHILIP C, GESTWICKI, JASON E · 2014 to 2017
$1.1MA Thermo-Fisher Scientific Q-Exactive HF Mass Spectrometry SystemS10OD021651 · OD · BOSTON UNIVERSITY MEDICAL CAMPUS · PI ZAIA, JOSEPH · 2016 to 2016
$580kNIGMS NIH HHS P41 GM104603NIGMS NIH HHS R01 GM065790NIGMS NIH HHS R01 GM095832NIGMS NIH HHS R01 GM105920NIGMS NIH HHS R01 GM105942NIGMS NIH HHS R01 GM109896NIGMS NIH HHS R24 GM134210NIH HHS S10 OD018455NIH HHS S10 OD021651NINDS NIH HHS R01 NS065244
Abstract
The cellular isoform of the prion protein (PrP
Indexed as
Molecular Dynamics SimulationMutationProtein DomainsAnimalsCell LineCopperCross-Linking ReagentsHumansMagnetic Resonance SpectroscopyMicePrion ProteinsProtein BindingProtein IsoformsTandem Mass SpectrometryCopperCross-Linking ReagentsPrion ProteinsProtein Isoformscoppercross-linkingion channelmass spectrometrymolecular dynamicsmutationNMRpatch clampprionprotein domain
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.