Evidence map›Paper›PMID 30955932›Full record

ArticleCurrent biology : CB2019

Noisy Cell-Size-Correlated Expression of Cyclin B Drives Probabilistic Cell-Size Homeostasis in Fission Yeast.

James O Patterson, Paul Rees, Paul Nurse

Open access · hybridAbstract read
In one paragraph

Article in Current biology : CB, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 49 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Regulation of organelle size and organization during development.Seminars in cell & developmental biology · 2023
    Review
  8. Article
  9. A quantitative and spatial analysis of cell cycle regulators during the fission yeast cycle.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  10. Article
  11. Article
  12. Imaging flow cytometry: a primer.Nature reviews. Methods primers · 2022
    Article
  13. Article
  14. Article
  15. Article
  16. Cell-size control.Current biology : CB · 2021
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

James O PattersonCell Cycle Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1ST, UK; College of Engineering, Swansea University, Bay Campus, Fabian Way, Swansea SA1 8EN, UK. Electronic address: james.patterson@crick.ac.uk.
Paul ReesCollege of Engineering, Swansea University, Bay Campus, Fabian Way, Swansea SA1 8EN, UK; Imaging Platform, Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, MA 02142, USA.
Paul NurseCell Cycle Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1ST, UK; Laboratory of Yeast Genetics and Cell Biology, Rockefeller University, 1230 York Ave, New York, NY 10065, USA.
Swansea University · GBThe Francis Crick Institute · GB

Funding

Biotechnology and Biological Sciences Research Council BB/N005163/1Biotechnology and Biological Sciences Research Council BB/P026818/1Cancer Research UK FC01121Medical Research Council FC01121Wellcome Trust 093917Wellcome Trust FC001121Wellcome Trust FC01121
6 · The paper itself

Abstract

How cells correct deviations from a mean cell size at mitosis remains uncertain. Classical cell-size homeostasis models are the sizer, timer, and adder [1]. Sizers postulate that cells divide at some threshold size; timers, that cells grow for a set time; and adders, that cells add a constant volume before division. Here, we show that a size-based probabilistic model of cell-size control at the G2/M transition (P(Div)) can generate realistic cell-size homeostasis in silico. In fission yeast cells, Cyclin B

Indexed as

HomeostasisCyclin BInterphaseMitosisSchizosaccharomycesSchizosaccharomyces pombe ProteinsCyclin BSchizosaccharomyces pombe ProteinsCDKcell divisioncell growthcell sizecyclincyclin-dependent kinasemitosissingle-cell biologysystems biology

Identifiers

PMID30955932
PMCPMC6488275
OpenAlexW2931448452

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.