ArticleBiological psychiatry2019
Nucleus Accumbens Cholinergic Interneurons Oppose Cue-Motivated Behavior.
Article in Biological psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
62 citing papers in PubMed, 109 citations in OpenAlex.
- Neurochemical drivers of effort: The roles of dopamine and beyond in physical and cognitive exertion.Neuroscience and biobehavioral reviews · 2026Review
- Dopamine projections to the basolateral amygdala enable reward prediction.bioRxiv : the preprint server for biology · 2026Article
- The parafascicular thalamus steers attention to facilitate learning.bioRxiv : the preprint server for biology · 2026Article
- Article
- Dopamine Supports Reward Prediction to Shape Reward-Pursuit Strategy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Dorsolateral striatal acetylcholine reorganizes neural ensembles to anticipate threat.bioRxiv : the preprint server for biology · 2025Article
- Ventral Striatal Cholinergic Interneurons Regulate Decision-Making or Motor Impulsivity Differentially across Learning and Biological Sex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Distinct spatially organized striatum-wide acetylcholine dynamics for the learning and extinction of Pavlovian associations.Nature communications · 2025Article
- Projections from ventral hippocampus to nucleus accumbens' cholinergic neurons are altered in depression.The Journal of general physiology · 2025Article
- Accumbal Dopamine and Acetylcholine Dynamics during Psychostimulant Sensitization.bioRxiv : the preprint server for biology · 2025Article
- An axonal brake on striatal dopamine output by cholinergic interneurons.Nature neuroscience · 2025Article
- Article
- Trans-synaptic modulation of cholinergic circuits tunes opioid reinforcement.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Mechanisms of nucleus accumbens deep brain stimulation in treating mental disorders.Fundamental research · 2025Review
- Article
- A mismatch between striatal cholinergic pauses and dopaminergic reward prediction errors.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Orbitofrontal cortex to dorsal striatum circuit is critical for incubation of oxycodone craving after forced abstinence.Addiction biology · 2024Article
- Behavioral tests of the insulin-cholinergic-dopamine link in nucleus accumbens and inhibition by high fat-high sugar diet in male and female rats.Physiology & behavior · 2024Article
- A dual-pathway architecture enables chronic stress to disrupt agency and promote habit formation.bioRxiv : the preprint server for biology · 2024Article
- Visualization of the existence of growth hormone secretagogue receptor in the rat nucleus accumbens.Molecular brain · 2024Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundEnvironmental reward-predictive stimuli provide a major source of motivation for adaptive reward pursuit behavior. This cue-motivated behavior is known to be mediated by the nucleus accumbens (NAc) core. The cholinergic interneurons in the NAc are tonically active and densely arborized and thus well suited to modulate NAc function. However, their causal contribution to adaptive behavior remains unknown. Here we investigated the function of NAc cholinergic interneurons in cue-motivated behavior.
methodsWe used chemogenetics, optogenetics, pharmacology, and a translationally analogous Pavlovian-to-instrumental transfer behavioral task designed to assess the motivating influence of a reward-predictive cue over reward-seeking actions in male and female rats.
resultsThe data show that NAc cholinergic interneuron activity critically opposes the motivating influence of appetitive cues. Chemogenetic inhibition of NAc cholinergic interneurons augmented cue-motivated behavior. Optical stimulation of acetylcholine release from NAc cholinergic interneurons prevented cues from invigorating reward-seeking behavior, an effect that was mediated by activation of β
conclusionsNAc cholinergic interneurons provide a critical regulatory influence over adaptive cue-motivated behavior and therefore are a potential therapeutic target for the maladaptive cue-motivated behavior that marks many psychiatric conditions, including addiction and depression.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.