Evidence map›Paper›PMID 30955492›Full record

ArticlePhilosophical transactions of the Royal Society of London. Series B, Biological sciences2019

Essential role of inverted repeat in Epstein-Barr virus IR-1 in B cell transformation; geographical variation of the viral genome.

Ray Bridges, Samantha Correia, Fanny Wegner, Cristina Venturini, Anne Palser, Robert E White, Paul Kellam, Judith Breuer, Paul J Farrell

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Article
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  4. Article
  5. Mono a Mano: ZBP1's Love-Hate Relationship with the Kissing Virus.International journal of molecular sciences · 2022
    Review
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  7. Article
  8. Review
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  10. Article
  11. Review
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  13. Article
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  15. Article
  16. In-Depth Bioinformatic Analyses ofFrontiers in microbiology · 2020
    Article
  17. Towards a multi-level and a multi-disciplinary approach to DNA oncovirus virulence.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Ray Bridges1 Section of Virology, Faculty of Medicine , Imperial College London, London W2 1PG , UK.
Samantha Correia1 Section of Virology, Faculty of Medicine , Imperial College London, London W2 1PG , UK.
Fanny Wegner2 Division of Infection and Immunity, University College London , Gower Street, London WC1E 6BT , UK.
Cristina Venturini2 Division of Infection and Immunity, University College London , Gower Street, London WC1E 6BT , UK.
Anne Palser3 Wellcome Trust Sanger Institute , Hinxton, Cambridge CB10 1SJ , UK.
Robert E White1 Section of Virology, Faculty of Medicine , Imperial College London, London W2 1PG , UK.
Paul Kellam1 Section of Virology, Faculty of Medicine , Imperial College London, London W2 1PG , UK.
Judith Breuer2 Division of Infection and Immunity, University College London , Gower Street, London WC1E 6BT , UK.
Paul J Farrell1 Section of Virology, Faculty of Medicine , Imperial College London, London W2 1PG , UK.
Imperial College London · GBUniversity College London · GBWellcome Sanger Institute · GB

Funding

Department of HealthMedical Research Council MR/N010388/1
6 · The paper itself

Abstract

Many regions of the Epstein-Barr virus (EBV) genome, repeated and unique sequences, contribute to the geographical variation observed between strains. Here we use a large alignment of curated EBV genome sequences to identify major sites of variation in the genome of type 1 EBV strains; the CAO deletion in latent membrane protein 1 (LMP1) is the most frequent major indel present in the unique regions of EBV strains from various parts of the world. Principal component analysis was used to identify patterns of sequence variation and nucleotide positions in the sequences that can distinguish EBV from some different geographical regions. Viral genome sequence variation also affects interpretation of genetic content; known genes, origins of replication and gene expression control regions explain most of the viral genome but there are still a few sections of unknown function. One of these EBV genome regions contains a large inverted repeat sequence (invR) within the IR-1 major internal repeat array. We deleted this invR sequence and showed that this abolished the ability of the virus to transform human B cells into lymphoblastoid cell lines. This article is part of the theme issue 'Silent cancer agents: multi-disciplinary modelling of human DNA oncoviruses'.

Indexed as

Epstein-Barr Virus InfectionsGenetic VariationGenome, ViralGeographyHerpesvirus 4, HumanHumansInverted Repeat SequencesViral ProteinsViral Proteinscell transformationEpstein–Barr virusrepeatsstrain variation

Identifiers

PMID30955492
PMCPMC6501908
OpenAlexW2937954408

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.