ArticleLangenbeck's archives of surgery2019
Mild sporadic primary hyperparathyroidism: high rate of multiglandular disease is associated with lower surgical cure rate.
Article in Langenbeck's archives of surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Challenges and unmet needs of [European journal of nuclear medicine and molecular imaging · 2026Article
- Article
- Long-term recurrence after parathyroidectomy in primary hyperparathyroidism-do predictors exist?Gland surgery · 2024Article
- Primary hyperparathyroidism: predictors of sporadic multi-gland disease.Endocrine connections · 2024Review
- Evolving Role of [Journal of clinical medicine · 2023Article
- Persistent and Recurrent Primary Hyperparathyroidism: Etiological Factors and Pre-Operative Evaluation.Sisli Etfal Hastanesi tip bulteni · 2023Review
- Efficacy and Safety of Ultrasound-Guided Radiofrequency Ablation for Primary Hyperparathyroidism: A Prospective Study.Korean journal of radiology · 2022Article
- Multiglandular Parathyroid Disease in Primary Hyperparathyroidism With Inconclusive Conventional Imaging.Physiological research · 2022Article
- Effect of Parathyroidectomy on Metabolic Homeostasis in Primary Hyperparathyroidism.Journal of clinical medicine · 2022Article
- How should we define cure after parathyroidectomy for normocalcemic primary hyperparathyroidism? A retrospective cohort study.Updates in surgery · 2021Article
- Review
- The changing face of reoperative parathyroidectomy: a single-centre comparison of 147 parathyroid reoperations.Annals of the Royal College of Surgeons of England · 2021Article
- Utility of a SecondAnnals of surgical oncology · 2020Article
- Review
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Authors and funding
10 authors.
Funding
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Abstract
backgroundMild primary hyperparathyroidism (serum calcium ≤ 2.85 mmol/L) is the most representative form of pHPT nowadays. The aim of this study was to evaluate its subtypes and the multiglandular disease (MGD) rate as it may lower the sensitivity of preoperative parathyroid scintigraphy and the surgical cure rate.
methodsWe retrospectively included patients with mild pHPT who underwent parathyroid dual-tracer scintigraphy with
resultsWe included 121 patients. Median preoperative serum calcium was 2.68 mmol/L and median PTH was 83.4 pg/mL. A total of 141 glands were resected (95 adenomas, 33 hyperplasias). The subtypes were 57% classic, 32.2% normohormonal, and 10.7% normocalcemic. MGD occurred in 23.5% of patients divided as 13%, 30%, and 64% respectively (p = 0.0011). The surgical cure rate was 85.2%. The normocalcemic form had lower cure rate than the normohormonal (45% vs 84%, p = 0.018) and classic forms (45% vs 93%, p = 0.0006). MIBI scintigraphy identified at least one abnormal lesion, later confirmed by the pathologist in 90/98 patients, making the sensitivity per patient 91.8% (95% CI 84.1-96.2%).
conclusionsMGD is strongly associated with mild pHPT, especially the normocalcemic form where it accounts for 64% of cases. Bilateral neck exploration should be performed in this population to improve the cure rate, even if the scintigraphy shows a single focus.
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