Evidence map›Paper›PMID 30954943›Full record

Trial reportJournal of nuclear medicine : official publication, Society of Nuclear Medicine2019

Early Detection of Multiorgan Light-Chain Amyloidosis by Whole-Body

Eric C Ehman, M Samir El-Sady, Marie F Kijewski, Yiu Ming Khor, Sophia Jacob, Frederick L Ruberg, Vaishali Sanchorawala, Heather Landau, Andrew J Yee, Giada Bianchi and 4 more

Open access · bronzeAbstract readClinical Trial
In one paragraph

Trial report in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 1 pooled it
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 1 synthesis or guideline pooled it, 85 citations in OpenAlex.

  1. Pooled it
  2. Multifocal skeletalEuropean journal of nuclear medicine and molecular imaging · 2026
    Article
  3. Imaging Advances in Light Chain Amyloidosis.Diagnostics (Basel, Switzerland) · 2026
    Review
  4. Review
  5. Total-bodyEuropean journal of nuclear medicine and molecular imaging · 2025
    Article
  6. Review
  7. Review
  8. Review
  9. Role of Total Body PET/CT in Inflammatory Disorders.Seminars in nuclear medicine · 2025
    Review
  10. Review
  11. Article
  12. Prognostic Value of Left VentricularJACC. Cardiovascular imaging · 2024
    Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Amyloid consults do not have to be vexing.Hematology. American Society of Hematology. Education Program · 2023
    Article
  18. Value of nuclide scintigraphy in the diagnosis and prognosis of cardiac amyloidosis.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2023
    Article
  19. [Giant tongue leading to dysphagia in light chain amyloidosis patient].Revista medica del Instituto Mexicano del Seguro Social · 2023
    Article
  20. Molecular Imaging of Systemic and Cardiac Amyloidosis: Recent Advances and Focus on the Future.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 1 country.

Eric C EhmanDivision of Nuclear Medicine, Department of Radiology, Brigham and Women's Hospital, Boston, Massachusetts.
M Samir El-SadyDivision of Nuclear Medicine, Department of Radiology, Brigham and Women's Hospital, Boston, Massachusetts.
Marie F KijewskiDivision of Nuclear Medicine, Department of Radiology, Brigham and Women's Hospital, Boston, Massachusetts.
Yiu Ming KhorDivision of Nuclear Medicine, Department of Radiology, Brigham and Women's Hospital, Boston, Massachusetts.
Sophia JacobDivision of Nuclear Medicine, Department of Radiology, Brigham and Women's Hospital, Boston, Massachusetts.
Frederick L RubergAmyloidosis Center, Boston University School of Medicine, Boston, Massachusetts.
Vaishali SanchorawalaAmyloidosis Center, Boston University School of Medicine, Boston, Massachusetts.
Heather LandauDivision of Medical Oncology, Memorial Sloan Kettering Medical Center, New York, New York.
Andrew J YeeDivision of Hematology and Oncology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts.
Giada BianchiDivision of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts.
Marcelo F Di CarliDivision of Nuclear Medicine, Department of Radiology, Brigham and Women's Hospital, Boston, Massachusetts.
Rodney H FalkCardiac Amyloidosis Program, Division of Cardiology, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
Hyewon HyunDivision of Nuclear Medicine, Department of Radiology, Brigham and Women's Hospital, Boston, Massachusetts.
Sharmila DorbalaDivision of Nuclear Medicine, Department of Radiology, Brigham and Women's Hospital, Boston, Massachusetts sdorbala@bwh.harvard.edu.
Brigham and Women's Hospital · USAmyloidosis Foundation · USBoston University · USDana-Farber Cancer Institute · USKettering Medical Center · USMassachusetts General Hospital · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

Immunoglobulin light-chain (AL) amyloidosis affects multiple systemic organs. However, determination of the precise extent of organ involvement remains challenging. Targeted amyloid imaging with

Indexed as

Positron Emission Tomography Computed TomographyAgedAmyloidAmyloidosisAniline CompoundsBiopsyBone MarrowEthylene GlycolsFemaleFluorine RadioisotopesHumansImage Processing, Computer-AssistedMaleMiddle AgedParotid GlandProspective StudiesAmyloidAniline CompoundsEthylene GlycolsflorbetapirFluorine-18Fluorine Radioisotopes18F-florbetapirALorganPET/CTsystemic light chain amyloidosis

Identifiers

PMID30954943
PMCPMC6735282
OpenAlexW2928963245

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.