Evidence map›Paper›PMID 30954832›Full record

Observational studyAmerican heart journal2019

Neck circumference and cardiovascular outcomes: Insights from the Jackson Heart Study.

Christopher A Pumill, Christopher G Bush, Melissa A Greiner, Michael E Hall, Shannon M Dunlay, Adolfo Correa, Lesley H Curtis, Takeki Suzuki, Chantelle Hardy, Chad T Blackshear and 2 more

Open access · greenAbstract readObservational Study
In one paragraph

Observational study in American heart journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Christopher A PumillDuke Clinical Research Institute, Duke University School of Medicine, Durham, NC; Department of Medicine, Duke University School of Medicine, Durham, NC.
Christopher G BushDepartment of Population Health Sciences, Duke University School of Medicine, Durham, NC.
Melissa A GreinerDepartment of Population Health Sciences, Duke University School of Medicine, Durham, NC.
Michael E HallDepartment of Medicine, University of Mississippi Medical Center, Jackson, MS.
Shannon M DunlayDepartments of Cardiovascular Medicine and Health Sciences Research, Mayo Clinic, Rochester, MN.
Adolfo CorreaDepartment of Medicine, University of Mississippi Medical Center, Jackson, MS.
Lesley H CurtisDepartment of Medicine, Duke University School of Medicine, Durham, NC.
Takeki SuzukiDepartment of Medicine, University of Mississippi Medical Center, Jackson, MS.
Chantelle HardyDepartment of Population Health Sciences, Duke University School of Medicine, Durham, NC.
Chad T BlackshearDepartment of Data Science, University of Mississippi Medical Center, Jackson, MS.
Emily C O'BrienDepartment of Population Health Sciences, Duke University School of Medicine, Durham, NC.
Robert J MentzDuke Clinical Research Institute, Duke University School of Medicine, Durham, NC; Department of Medicine, Duke University School of Medicine, Durham, NC. Electronic address: robert.mentz@duke.edu.
Duke University · USUniversity of Mississippi Medical Center · USClinical Research Institute · USJackson Memorial Hospital · USMayo Clinic in Florida · US

Funding

TRANSFORM-HF CCCU01HL125511 · NHLBI · YALE UNIVERSITY · PI MENTZ, ROBERT JOHN, VELAZQUEZ, ERIC J · 2017 to 2021
$7.7M
Incorporation of a Hypertension Working Group into the Jackson Heart StudyR01HL117323 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LEWIS, CORA E, OGEDEGBE, OLUGBENGA G. · 2013 to 2024
$7.2M
REHAB-HF: A Trial of Rehabilitation Therapy in Older Acute Heart Failure PatientsR01AG045551 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI KITZMAN, DALANE W · 2014 to 2018
$6.8M
Heart Failure Clinical Research Network Regional Clinical Center (U10)U10HL110312 · NHLBI · DUKE UNIVERSITY · PI FELKER, GARY M · 2012 to 2018
$3.5M
A Collaboration for Improving Outcomes of African Americans with Heart FailureR01HL117305 · NHLBI · DUKE UNIVERSITY · PI CURTIS, LESLEY H, O'BRIEN, EMILY C · 2013 to 2016
$963k
Renal Sinus Fat, Hypertension, and Altered Kidney FunctionK08DK099415 · NIDDK · UNIVERSITY OF MISSISSIPPI MED CTR · PI HALL, MICHAEL EDWARD · 2015 to 2019
$791k
Midcareer Investigator Award in Patient-Oriented Research in Human HypertensionK24HL125704 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SHIMBO, DAICHI · 2015 to 2019
$573k
NHLBI NIH HHS HHSN268201300046CNHLBI NIH HHS HHSN268201300047CNHLBI NIH HHS HHSN268201300048CNHLBI NIH HHS HHSN268201300049CNHLBI NIH HHS HHSN268201300050CNHLBI NIH HHS K24 HL125704NHLBI NIH HHS R01 HL117305NHLBI NIH HHS R01 HL117323NHLBI NIH HHS U01 HL125511NHLBI NIH HHS U10 HL110312NIA NIH HHS R01 AG045551NIDDK NIH HHS K08 DK099415
6 · The paper itself

Abstract

backgroundEmerging data suggest that neck circumference (NC) is associated with cardiometabolic risk factors. Limited research is available regarding the association between NC and cardiovascular outcomes in African Americans.

methodsUsing data from the Jackson Heart Study, we included participants with recorded NC measurements at baseline (2000-2004). Baseline characteristics for the included population were summarized by tertiles of NC. We then calculated age- and sex-adjusted cumulative incidence of clinical cardiovascular outcomes and performed Cox proportional-hazards with stepwise models.

resultsOverall, 5,290 participants were categorized into tertiles of baseline NC defined as ≤37 cm (n = 2179), 38-40 cm (n = 1552), and >40 cm (n = 1559). After adjusting for age and sex, increasing NC was associated with increased risk of heart failure (HF) hospitalization (cumulative incidence = 13.4% [99% CI, 10.7-16.7] in the largest NC tertile vs 6.5% [99% CI, 4.7-8.8] in the smallest NC tertile), but not mortality, stroke, myocardial infarction, or coronary heart disease (all P ≥ .1). Following full risk adjustment, there was a nominal increase in the risk of HF hospitalization with increasing NC, but this was not statistically significant (hazard ratio per 1-cm increase, 1.04 [99% CI, 0.99-1.10], P = .06).

conclusionsIn this large cohort of African American individuals, a larger NC was associated with increased risk for HF hospitalization following adjustment for age and sex, but this risk was not statistically significant after adjusting for other clinical variables. Although NC is not independently associated with increased risk for cardiovascular events, it may offer prognostic information particularly related to HF hospitalization.

Indexed as

Black or African AmericanAge FactorsBody SizeCardiovascular DiseasesFemaleFollow-Up StudiesHumansIncidenceMaleMiddle AgedNeckPrognosisProspective StudiesRisk AssessmentRisk FactorsSex Factors

Identifiers

PMID30954832
PMCPMC6535120
OpenAlexW2920987600

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.