Evidence map›Paper›PMID 30954728›Full record

ArticleEnvironment international2019

A breast cancer case-control study of polybrominated diphenyl ether (PBDE) serum levels among California women.

Susan Hurley, Debbie Goldberg, June-Soo Park, Myrto Petreas, Leslie Bernstein, Hoda Anton-Culver, Susan L Neuhausen, David O Nelson, Peggy Reynolds

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environment international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Exposure to brominated flame retardantsFrontiers in endocrinology · 2024
    Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Review
  13. Polybrominated diphenyl ethers in the environmental systems: a review.Journal of environmental health science & engineering · 2021
    Review
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Susan HurleyDepartment of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA; Cancer Prevention Institute of California, Berkeley, CA, USA. Electronic address: Susan.Hurley@ucsf.edu.
Debbie GoldbergDepartment of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA; Cancer Prevention Institute of California, Berkeley, CA, USA.
June-Soo ParkEnvironmental Chemistry Laboratory, Department of Toxic Substances Control, Berkeley, CA, USA.
Myrto PetreasEnvironmental Chemistry Laboratory, Department of Toxic Substances Control, Berkeley, CA, USA.
Leslie BernsteinDepartment of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA, USA.
Hoda Anton-CulverDepartment of Epidemiology, School of Medicine, University of California Irvine, Irvine, CA, USA.
Susan L NeuhausenDepartment of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA, USA.
David O NelsonCancer Prevention Institute of California, Berkeley, CA, USA.
Peggy ReynoldsDepartment of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA; Cancer Prevention Institute of California, Berkeley, CA, USA; Stanford University School of Medicine, Department of Health Research and Policy, Stanford, CA, USA.
Cancer Prevention Institute of California · USCalifornia Department of Toxic Substances Control · USCity of Hope · USUniversity of California, Irvine · US

Funding

CALIFORNIA TEACHERS STUDYR01CA077398 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BERNSTEIN, LESLIE · 1998 to 2014
$29.7M
NCI NIH HHS R01 CA077398
6 · The paper itself

Abstract

purposePolybrominated diphenyl ethers (PBDEs) are among the most persistent and pervasive global environmental contaminants. Their toxic and endocrine-disrupting properties have made them a focus of concern for breast cancer. Our objective was to evaluate the risk of breast cancer associated with serum PBDE levels in a case-control study nested within the California Teachers Study.

methodsParticipants were 902 women with invasive breast cancer (cases) and 936 with no such diagnosis (controls) who provided 10 mL of blood and were interviewed between 2011 and 2015. Blood samples were collected from cases an average of 35 months after diagnosis. PBDEs were measured in serum using automated solid phase extraction and gas chromatography/high resolution mass spectrometry. Statistical analyses were restricted to the three congeners with detection frequencies ≥75%: 2,2',4,4'-tetrabromodiphenyl ether (BDE-47), 2,2',4,4',6-pentabromodiphenyl ether (BDE-100), and 2,2',4,4',5,5'-hexabromodiphenyl ether (BDE-153). Unconditional logistic regression was used to estimate multivariable-adjusted odds ratios (ORs) and their 95% confidence intervals (CI) for each BDE congener, adjusting for serum lipids and other potential confounders.

resultsThe OR for each of the three BDE congeners was close to unity with a CI that included one. Analyses stratified by menopausal status, tumor hormone responsiveness, BMI, and changes in body weight yielded similarly null results.

conclusionsOur findings provide no evidence that serum levels of BDE-47, BDE-100 or BDE-153 are associated with breast cancer risk. These results should be interpreted in the context of study limitations which include the reliance on PBDE measurements that may not represent pre-diagnostic, early-life or chronic exposures and a lack of information on genetic polymorphisms and other factors which may affect endogenous estrogen levels.

Indexed as

AdultBreast NeoplasmsCaliforniaCase-Control StudiesEndocrine DisruptorsFemaleGas Chromatography-Mass SpectrometryHalogenated Diphenyl EthersHumansLogistic ModelsOdds RatioRisk FactorsSolid Phase ExtractionEndocrine DisruptorsHalogenated Diphenyl EthersBreast cancer riskCase-controlPBDEsPersistent organic pollutantsPolybrominated diphenyl ethers

Identifiers

PMID30954728
PMCPMC6522143
OpenAlexW2927139194

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.