ArticleNeuroImage2019
Resting state functional connectivity and cognitive task-related activation of the human claustrum.
Article in NeuroImage, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 4 of them syntheses that pooled it.
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Who cites it
56 citing papers in PubMed, 4 syntheses or guidelines pooled it, 91 citations in OpenAlex.
- Mapping common and distinct brain correlates among cognitive flexibility tasks: concordant evidence from meta-analyses.Brain imaging and behavior · 2025Pooled it
- Human lesions and animal studies link the claustrum to perception, salience, sleep and pain.Brain : a journal of neurology · 2022Pooled it
- Insula activity in resting-state differentiates bipolar from unipolar depression: a systematic review and meta-analysis.Scientific reports · 2021Pooled it
- Clinical and Structural Differences in Delusions Across Diagnoses: A Systematic Review.Frontiers in integrative neuroscience · 2021Pooled it
- New functional insights from the monkey claustrum.National science review · 2026Review
- Multiscale characterization of the human claustrum from histology to MRI.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- The primate claustrum as a hub for precision weighting of prediction errors across the cortical hierarchy.PLoS biology · 2026Article
- The human claustrum supports cognitive networks for externally and internally driven task demands.PLoS biology · 2026Article
- Nurr1 Orchestrates Claustrum Development and Functionality.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- The effect of psilocin on neurotransmitters release in the claustrum and on rat behavior.Pharmacological reports : PR · 2026Article
- The claustrum enhances neural variability by modulating the responsiveness of the prefrontal cortex.Nature communications · 2025Article
- Topographic organisation of the claustrum-amygdala-prefrontal circuitry in the common marmoset (Callithrix jacchus).Brain structure & function · 2025Article
- The Human Claustrum Activates Across Multiple Cognitive Control Tasks.The European journal of neuroscience · 2025Article
- Serotonin and psilocybin activate 5-HTNature communications · 2025Article
- A Contrast-Agnostic Method for Ultra-High Resolution Claustrum Segmentation.Human brain mapping · 2025Article
- The human brainstem's red nucleus was upgraded to support goal-directed action.Nature communications · 2025Article
- The Role of Claustrum in Incubation of Opioid Seeking after Electric Barrier-Induced Voluntary Abstinence in Male and Female Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- The Role of the Claustrum in Parkinson's Disease and Vascular Parkinsonism: A Matter of Network?Life (Basel, Switzerland) · 2025Review
- Resting-state functional connectivity of the marmoset claustrum.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Single-unit activity in the anterior claustrum during memory retrieval after trace fear conditioning.PloS one · 2025Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Structural and functional analyses of the human claustrum, a poorly understood telencephalic gray matter structure, are hampered by its sheet-like anatomical arrangement. Here, we first describe a functional magnetic resonance imaging (fMRI) method to reveal claustrum signal with no linear relationship with adjacent regions in human subjects. We applied this approach to resting state functional connectivity (RSFC) analysis of the claustrum at high resolution (1.5 mm isotropic voxels) using a 7T dataset (n = 20) and a separate 3T dataset for replication (n = 35). We then assessed claustrum activation during performance of a cognitive task, the multi-source interference task, at 3T (n = 33). Extensive functional connectivity was observed between claustrum and cortical regions associated with cognitive control, including anterior cingulate, prefrontal and parietal cortices. Cognitive task performance was associated with widespread activation and deactivation that overlapped with the cortical areas showing functional connectivity to the claustrum. Furthermore, during high cognitive conflict conditions of the task, the claustrum was significantly activated at the onset of the task, but not during the remainder of the difficult condition. Both of these findings suggest that the human claustrum can be functionally isolated with fMRI, and that it may play a role in cognitive control, and specifically task switching, independent of sensorimotor processing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.