ArticleMechanisms of ageing and development2019
Sublethal whole-body irradiation causes progressive premature frailty in mice.
Article in Mechanisms of ageing and development, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 36 citations in OpenAlex.
- Effects of aging on anticancer therapy in murine cancer models.Cancer metastasis reviews · 2025Review
- Single‑cell RNA‑Seq reveals PBMC profile alterations in a patient following a radiation accident.Experimental and therapeutic medicine · 2025Article
- Digital humanistic program to manage premature frailty in young breast cancer survivors with gender perspective.NPJ digital medicine · 2025Article
- Siwu decoction mitigates radiation-induced immune senescence by attenuating hematopoietic damage.Chinese medicine · 2024Article
- Model of Accelerated Aging in CB6F2 Mice Induced by Ionizing Radiation.Bulletin of experimental biology and medicine · 2024Article
- Mild Uncoupling of Mitochondria Synergistically Enhances Senolytic Specificity and Sensitivity of BH3 Mimetics.Aging biology · 2024Article
- Nicotinamide riboside intervention alleviates hematopoietic system injury of ionizing radiation-induced premature aging mice.Aging cell · 2023Article
- Article
- Further Characterization of Multi-Organ DEARE and Protection by 16,16 Dimethyl Prostaglandin E2 in a Mouse Model of the Hematopoietic Acute Radiation Syndrome.Radiation research · 2023Article
- Cellular senescence: a double-edged sword in cancer therapy.Frontiers in oncology · 2023Review
- Preclinical trials in Alzheimer's disease: Sample size and effect size for behavioural and neuropathological outcomes in 5xFAD mice.PloS one · 2023Article
- Article
- Physiological Systems in Promoting Frailty.Comprehensive Physiology · 2022Review
- Induction of Accelerated Aging in a Mouse Model.Cells · 2022Review
- Radiation-Induced Osteocyte Senescence Alters Bone Marrow Mesenchymal Stem Cell Differentiation Potential via Paracrine Signaling.International journal of molecular sciences · 2021Article
- The degree of frailty as a translational measure of health in aging.Nature aging · 2021Review
- Phenotypic Frailty Assessment in Mice: Development, Discoveries, and Experimental Considerations.Physiology (Bethesda, Md.) · 2020Review
- In vivo modeling recapitulates radiotherapy delivery and late-effect profile for childhood medulloblastoma.Neuro-oncology advancesArticle
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
There is an unmet need to develop and validate therapies that can treat or at least prevent premature therapy-induced frailty, multi-morbidity and mortality in long-term tumour survivors. In an approach to develop a first mouse model for therapy-induced long-term frailty, we irradiated male C57Bl/6 mice at 5-6 months of age sub-lethally with 3 × 3 Gy (whole body) and assessed subsequent frailty for up to 6 months using a Rockwood-type frailty index (FI). Frailty scorers were trained to obtain excellent inter- and intra-observer reproducibility. Irradiated mice developed progressive frailty approximately twice as fast as controls. This was premature frailty; it was phenotypically identical to that in non-irradiated mice at higher age. As expected, frailty was associated with decreased cognition and predicted mortality. In irradiated mice, frailty and neuromuscular performance, measured by Rotarod and Hanging Wire tests, were not associated with each other, probably because of long-term decreased body weights after irradiation. We conclude that progressive frailty following sub-lethal irradiation comprises a sensitive and easy to use test bed for interventions to stop premature ageing in long-term tumour survivors.
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